Long Noncoding RNA ZFAS1 promotes the progression of colonic cancer by modulating ZEB1 expression.

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Abstract

Long non-coding RNA ZFAS1 (zinc finger antisense 1) is frequently amplified in hepatocellular carcinoma and promotes metastasis by increasing zinc finger E-box binding homeobox 1 (ZEB1), which can potentiate the progression of epithelial-to-mesenchymal transition (EMT). However, the expression pattern and role of ZFAS1 in colonic cancer remains unknown. The present study aimed to investigate the role of ZFAS1 and its clinical significance in colonic cancer.

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Author and article information

Journal

Journal ID (iso-abbrev): J. Gastroenterol. Hepatol.

Title: Journal of gastroenterology and hepatology

Publisher: Wiley-Blackwell

ISSN (Electronic): 1440-1746

ISSN (Print): 0815-9319

Publication date (Electronic): Nov 11 2016

Affiliations

[1 ] Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine.

[2 ] Department of General Surgery, Anqing Hospital Affiliated to Anhui Medical University.

Article

DOI: 10.1111/jgh.13646

PubMed ID: 27862275

SO-VID: cd9b1d9f-a938-4333-9f22-5a343b439fe4

History

Keywords: EMT,LncRNA ZFAS1,ZEB1,colonic cancer

Data availability:

Keywords: EMT, LncRNA ZFAS1, ZEB1, colonic cancer

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