Imaging Gliomas with Nanoparticle-Labeled Stem Cells Translated title: 纳米颗粒标记干细胞对胶质瘤进行成像的最新进展

Abstract

Objective:

Gliomas are the most common neoplasm of the central nervous system (CNS); however, traditional imaging techniques do not show the boundaries of tumors well. Some researchers have found a new therapeutic mode to combine nanoparticles, which are nanosized particles with various properties for specific therapeutic purposes, and stem cells for tracing gliomas. This review provides an introduction of the basic understanding and clinical applications of the combination of stem cells and nanoparticles as a contrast agent for glioma imaging.

Data Sources:

Studies published in English up to and including 2017 were extracted from the PubMed database with the selected key words of “stem cell,” “glioma,” “nanoparticles,” “MRI,” “nuclear imaging,” and “Fluorescence imaging.”

Study Selection:

The selection of studies focused on both preclinical studies and basic studies of tracking glioma with nanoparticle-labeled stem cells.

Results:

Studies have demonstrated successful labeling of stem cells with multiple types of nanoparticles. These labeled stem cells efficiently migrated to gliomas of varies models and produced signals sensitively captured by different imaging modalities.

Conclusion:

The use of nanoparticle-labeled stem cells is a promising imaging platform for the tracking and treatment of gliomas.

摘要

目的：

胶质瘤是中枢神经系统最常见的肿瘤，传统的显像方式对其边缘显像欠佳。有学者发现可通过利用具有纳米级别尺寸和针对特定治疗目的具有多种属性的纳米颗粒与干细胞相结合，从而对胶质瘤进行示踪。本文对利用纳米颗粒标记干细胞作为胶质瘤成像的显像剂这一策略进行了文献综述，并介绍其基本原理和临床应用。

数据源：

本文利用PubMed数据库对包括2017年以前的文献通过“干细胞”、 “胶质瘤”、 “核磁共振”、 “核成像”以及“荧光成像”等关键词进行文献筛选。

研究选择：

本文对纳入了有关纳米颗粒标记干细胞对胶质瘤进行成像的基础研究和临床前研究。结果： 许多研究表明，纳米颗粒可成功地对干细胞进行标记。被标记的干细胞在不同胶质瘤模型中可有效地向胶质瘤迁移、产生信号并用多种影像学技术进行成像。

结果：

许多研究表明，纳米颗粒可成功地对干细胞进行标记。被标记的干细胞在不同胶质瘤模型中可有效地向胶质瘤迁移、产生信号并用多种影像学技术进行成像。

结论：

利用纳米颗粒标记的干细胞是一种对胶质瘤进行显像和治疗的具有应用前景的技术平台。