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      Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans.

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          Abstract

          Many conditions that shift cells from states of nutrient utilization and growth to states of cell maintenance extend lifespan. We have carried out a systematic lifespan analysis of conditions that inhibit protein synthesis. We find that reducing the levels of ribosomal proteins, ribosomal-protein S6 kinase or translation-initiation factors increases the lifespan of Caenorhabditis elegans. These perturbations, as well as inhibition of the nutrient sensor target of rapamycin (TOR), which is known to increase lifespan, all increase thermal-stress resistance. Thus inhibiting translation may extend lifespan by shifting cells to physiological states that favor maintenance and repair. Interestingly, different types of translation inhibition lead to one of two mutually exclusive outputs, one that increases lifespan and stress resistance through the transcription factor DAF-16/FOXO, and one that increases lifespan and stress resistance independently of DAF-16. Our findings link TOR, but not sir-2.1, to the longevity response induced by dietary restriction (DR) in C. elegans, and they suggest that neither TOR inhibition nor DR extends lifespan simply by reducing protein synthesis.

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          Author and article information

          Journal
          Aging Cell
          Aging cell
          Wiley
          1474-9718
          1474-9718
          Feb 2007
          : 6
          : 1
          Affiliations
          [1 ] Department of Biochemistry and Biophysics, University of California, 600 16th Street, San Francisco, CA 94158, USA.
          Article
          ACE267
          10.1111/j.1474-9726.2006.00267.x
          17266679
          d0c83b1c-b857-4d88-b333-ac4534a9022b
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