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      Bitungolides A-F, new polyketides from the Indonesian sponge Theonella cf. swinhoei.

      Journal of Natural Products
      Animals, Dose-Response Relationship, Drug, Enzyme Inhibitors, chemistry, isolation & purification, pharmacology, Indonesia, Microtubules, drug effects, Molecular Conformation, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Phosphoric Monoester Hydrolases, antagonists & inhibitors, Porifera, Pyrones, Spectroscopy, Fourier Transform Infrared, X-Ray Diffraction

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          Abstract

          Six new polyketides, bitungolides A-F (1-6), have been isolated from the Indonesian sponge Theonella cf. swinhoei and their structures elucidated by spectroscopic data and X-ray diffraction analysis. The bitungolides are a new class of Theonella metabolites that inhibit dual-specificity phosphatase VHR.

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