For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
5
views
27
references
 Top references
cited by
13
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      831
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Chalcones Repressed the AURKA and MDR Proteins Involved in Metastasis and Multiple Drug Resistance in Breast Cancer Cell Lines

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          In the present investigation, trans-chalcone and licochalcone A were tested against MCF-7 and BT-20 breast cancer cell lines for anti-tumor activity. We found that both chalcones down regulated important genes associated to cancer development and inhibited cell migration of metastatic cells (BT-20). Finally, we observed that licochalcone A reduces the MDR-1 protein, while both chalcones suppress the AURKA protein in a dose-dependent manner. In conclusion, we observed the trans-chalcone and licochalcone A affected the cell viability of breast cancer cell lines MCF-7 and BT-20 and presents anti-metastatic and anti-resistance potential, by the repression of AUKA and MDR-1 proteins.

          Related collections

          Most cited references27

          • Record: found
          • Abstract: found
          • Article: not found

          Tumor metastasis: molecular insights and evolving paradigms.

          Scott Valastyan, Robert A Weinberg (2011)
          Metastases represent the end products of a multistep cell-biological process termed the invasion-metastasis cascade, which involves dissemination of cancer cells to anatomically distant organ sites and their subsequent adaptation to foreign tissue microenvironments. Each of these events is driven by the acquisition of genetic and/or epigenetic alterations within tumor cells and the co-option of nonneoplastic stromal cells, which together endow incipient metastatic cells with traits needed to generate macroscopic metastases. Recent advances provide provocative insights into these cell-biological and molecular changes, which have implications regarding the steps of the invasion-metastasis cascade that appear amenable to therapeutic targeting. Copyright © 2011 Elsevier Inc. All rights reserved.
          Article 0 comments Cited 1442 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: found
            Is Open Access

            Choosing the right cell line for breast cancer research

            Deborah Holliday, Valerie Speirs (2011)
            Breast cancer is a complex and heterogeneous disease. Gene expression profiling has contributed significantly to our understanding of this heterogeneity at a molecular level, refining taxonomy based on simple measures such as histological type, tumour grade, lymph node status and the presence of predictive markers like oestrogen receptor and human epidermal growth factor receptor 2 (HER2) to a more sophisticated classification comprising luminal A, luminal B, basal-like, HER2-positive and normal subgroups. In the laboratory, breast cancer is often modelled using established cell lines. In the present review we discuss some of the issues surrounding the use of breast cancer cell lines as experimental models, in light of these revised clinical classifications, and put forward suggestions for improving their use in translational breast cancer research.
            Article 0 comments Cited 577 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              The global burden of women’s cancers: a grand challenge in global health

              Groesbeck P. Parham, Natasha Kassami, Lesong Conteh … (2017)
              Every year, more than 2 million women worldwide are diagnosed with breast or cervical cancer, yet where a woman lives, her socioeconomic status, and agency largely determines whether she will develop one of these cancers and will ultimately survive. In regions with scarce resources, fragile or fragmented health systems, cancer contributes to the cycle of poverty. Proven and cost-effective interventions are available for both these common cancers, yet for so many women access to these is beyond reach. These inequities highlight the urgent need in low-income and middle-income countries for sustainable investments in the entire continuum of cancer control, from prevention to palliative care, and in the development of high-quality population-based cancer registries. In this first paper of the Series on health, equity, and women's cancers, we describe the burden of breast and cervical cancer, with an emphasis on global and regional trends in incidence, mortality, and survival, and the consequences, especially in socioeconomically disadvantaged women in different settings.
              Article 0 comments Cited 350 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Molecules
                Journal ID (iso-abbrev): Molecules
                Journal ID (publisher-id): molecules
                Title: Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
                Publisher: MDPI
                ISSN (Electronic): 1420-3049
                Publication date (Electronic): 13 August 2018
                Publication date Collection: August 2018
                Volume: 23
                Issue: 8
                Electronic Location Identifier: 2018
                Affiliations
                [1 ]Biotechnology Unit, University of Ribeirão Preto, SP, Av. Costábile Romano, 2201, Ribeirão Preto, SP, CEP 14096-900, Brazil; tattytk@ 123456hotmail.com (T.T.K.); taynalink@ 123456yahoo.com.br (T.M.B.); thaismesquita26@ 123456hotmail.com (T.B.M.); lfbortolotto@ 123456gmail.com (L.F.B.B.); biel-189@ 123456hotmail.com (G.S.); tabitencourt@ 123456yahoo.com.br (T.A.B.); mmarins@ 123456gmb.bio.br (M.M.)
                [2 ]Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA; sbaek2@ 123456utk.edu
                Author notes
                [* ]Correspondence: afachin@ 123456unaerp.br ; Tel.: +55-16-3603-7017; Fax: +55-16-3603-7030
                [†]

                These authors contributed equally to this work.

                Author information
                https://orcid.org/0000-0001-5287-0866
                https://orcid.org/0000-0001-5287-0866
                https://orcid.org/0000-0001-5287-0866
                https://orcid.org/0000-0001-7389-4023
                Article
                Publisher ID: molecules-23-02018
                DOI: 10.3390/molecules23082018
                PMC ID: 6222917
                PubMed ID: 30104527
                SO-VID: d2ff7a07-58a0-49a5-aba6-15dde4edb426
                Copyright © © 2018 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 29 June 2018
                Date accepted : 06 August 2018
                Categories
                Subject: Article

                Keywords: flavonoids,bt-20,mcf-7,metastasis,mdr
                Data availability:
                Keywords: flavonoids, bt-20, mcf-7, metastasis, mdr

                Comments

                Comment on this article

                scite_

                Similar content831

                See all similar

                Cited by13

                See all cited by

                Most referenced authors736

                See all reference authors