Function of the Isolated Perfused Kidney in Young and Adult Spontaneously Hypertensive and Dahl Salt-Sensitive Rats

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Abstract

The aim of the study was to find a possible explanation for the development of hypertension in two genetically hypertensive rat strains. Isolated kidneys from spontaneously hypertensive rats (SHR) and Dahl salt-sensitive rats (Dahl-S) kept on a low-salt diet were perfused at normotensive pressure (110 mm Hg). In adult (12-week-old) rats, no significant change in either parameter of kidney function was found in the two strains. In contrast, substantial changes were observed in both strains at the age of 6 weeks. Glomerular filtration rate and filtration fraction were similarly reduced both in SHR and Dahl-S rats. In SHR, the amount of sodium excreted was reduced in parallel to the GFR decrease. Sodium excretion was lower in Dahl-S than in Dahl-R due to the former higher Na<sup>+</sup> tubular reabsorption. The same was true for water excretion and its tubular reabsorption in this strain. In conclusion, the decreased amount of sodium excreted found in young SHR and Dahl-S might contribute to the development of hypertension in these strains. However, the reasons for this reduction are different in these two strains. In SHR, it results from decreased GFR whereas, in Dahl-S it is mainly due to increased tubular reabsorption.

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Author and article information

Journal

Journal ID (publisher-id): KBR

Journal ID (nlm-ta): Kidney Blood Press Res

Journal ID (doi): 10.1159/issn.1420-4096

Title: Kidney and Blood Pressure Research

Publisher: S. Karger AG

ISSN (Print): 1420-4096

ISSN (Electronic): 1423-0143

Publication date Subscription-year: 2002

Publication date (Print): 2002

Publication date (Electronic): 28 November 2002

Volume: 25

Issue: 5

Pages: 315-321

Affiliations

Center for Experimental Cardiovascular Research, Institute for Clinical and Experimental Medicine and Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

Article

Publisher ID: 66791 Other ID: Kidney Blood Press Res 2002;25:315–321

DOI: 10.1159/000066791

PubMed ID: 12435878

SO-VID: d340d693-708d-4505-8246-a0ce54554e50

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 08 July 2002

Page count

Figures: 2, Tables: 2, References: 16, Pages: 7

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