0
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Function of the Isolated Perfused Kidney in Young and Adult Spontaneously Hypertensive and Dahl Salt-Sensitive Rats

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The aim of the study was to find a possible explanation for the development of hypertension in two genetically hypertensive rat strains. Isolated kidneys from spontaneously hypertensive rats (SHR) and Dahl salt-sensitive rats (Dahl-S) kept on a low-salt diet were perfused at normotensive pressure (110 mm Hg). In adult (12-week-old) rats, no significant change in either parameter of kidney function was found in the two strains. In contrast, substantial changes were observed in both strains at the age of 6 weeks. Glomerular filtration rate and filtration fraction were similarly reduced both in SHR and Dahl-S rats. In SHR, the amount of sodium excreted was reduced in parallel to the GFR decrease. Sodium excretion was lower in Dahl-S than in Dahl-R due to the former higher Na<sup>+</sup> tubular reabsorption. The same was true for water excretion and its tubular reabsorption in this strain. In conclusion, the decreased amount of sodium excreted found in young SHR and Dahl-S might contribute to the development of hypertension in these strains. However, the reasons for this reduction are different in these two strains. In SHR, it results from decreased GFR whereas, in Dahl-S it is mainly due to increased tubular reabsorption.

          Related collections

          Author and article information

          Journal
          KBR
          Kidney Blood Press Res
          10.1159/issn.1420-4096
          Kidney and Blood Pressure Research
          S. Karger AG
          1420-4096
          1423-0143
          2002
          2002
          28 November 2002
          : 25
          : 5
          : 315-321
          Affiliations
          Center for Experimental Cardiovascular Research, Institute for Clinical and Experimental Medicine and Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
          Article
          66791 Kidney Blood Press Res 2002;25:315–321
          10.1159/000066791
          12435878
          © 2002 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Figures: 2, Tables: 2, References: 16, Pages: 7
          Product
          Self URI (application/pdf): https://www.karger.com/Article/Pdf/66791
          Categories
          Original Paper

          Comments

          Comment on this article