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      Function of the Isolated Perfused Kidney in Young and Adult Spontaneously Hypertensive and Dahl Salt-Sensitive Rats

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          The aim of the study was to find a possible explanation for the development of hypertension in two genetically hypertensive rat strains. Isolated kidneys from spontaneously hypertensive rats (SHR) and Dahl salt-sensitive rats (Dahl-S) kept on a low-salt diet were perfused at normotensive pressure (110 mm Hg). In adult (12-week-old) rats, no significant change in either parameter of kidney function was found in the two strains. In contrast, substantial changes were observed in both strains at the age of 6 weeks. Glomerular filtration rate and filtration fraction were similarly reduced both in SHR and Dahl-S rats. In SHR, the amount of sodium excreted was reduced in parallel to the GFR decrease. Sodium excretion was lower in Dahl-S than in Dahl-R due to the former higher Na<sup>+</sup> tubular reabsorption. The same was true for water excretion and its tubular reabsorption in this strain. In conclusion, the decreased amount of sodium excreted found in young SHR and Dahl-S might contribute to the development of hypertension in these strains. However, the reasons for this reduction are different in these two strains. In SHR, it results from decreased GFR whereas, in Dahl-S it is mainly due to increased tubular reabsorption.

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          Author and article information

          Kidney Blood Press Res
          Kidney and Blood Pressure Research
          S. Karger AG
          28 November 2002
          : 25
          : 5
          : 315-321
          Center for Experimental Cardiovascular Research, Institute for Clinical and Experimental Medicine and Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
          66791 Kidney Blood Press Res 2002;25:315–321
          © 2002 S. Karger AG, Basel

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          Page count
          Figures: 2, Tables: 2, References: 16, Pages: 7
          Self URI (application/pdf): https://www.karger.com/Article/Pdf/66791
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