66
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Controlling the elongation phase of transcription with P-TEFb.

      1 ,
      Molecular cell
      Elsevier BV

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The positive transcription elongation factor b (P-TEFb) is a cyclin-dependent kinase that controls the elongation phase of transcription by RNA polymerase II (RNAPII). This process is made possible by the reversal of effects of negative elongation factors that include NELF and DSIF. In complex organisms, elongation control is critical for the regulated expression of most genes. In those organisms, the function of P-TEFb is influenced negatively by HEXIM proteins and 7SK snRNA and positively by a variety of recruiting factors. Phylogenetic analyses of the components of the human elongation control machinery indicate that the number of mechanisms utilized to regulate P-TEFb function increased as organisms developed more complex developmental patterns.

          Related collections

          Author and article information

          Journal
          Mol Cell
          Molecular cell
          Elsevier BV
          1097-2765
          1097-2765
          Aug 04 2006
          : 23
          : 3
          Affiliations
          [1 ] Department of Medicine, Microbiology and Immunology, Rosalind Russell Medical Research Center, University of California, San Francisco, San Francisco, California 94143, USA. matija.peterlin@ucsf.edu
          Article
          S1097-2765(06)00429-1
          10.1016/j.molcel.2006.06.014
          16885020
          d472ad1b-6b42-4deb-982e-6fcc3e582938
          History

          Comments

          Comment on this article