Panax notoginseng saponin is superior to aspirin in inhibiting platelet adhesion to injured endothelial cells through COX pathway in vitro.

Kou, Na; Yang, Lin; Zhang, Ying Jun; Shi, Da-Zhuo; Xu, Yong-Gang; Xue, Mei; Wang, Ming-Ming; Miao, Yu

doi:10.1016/j.thromres.2016.03.022

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Panax notoginseng saponin is superior to aspirin in inhibiting platelet adhesion to injured endothelial cells through COX pathway in vitro.

Author(s): Ming-Ming Wang ¹ , Mei Xue ¹ , Yong-Gang Xu ¹ , Yu Miao ¹ , Na Kou ² , Lin Yang ¹ , Ying Zhang ² , Da-Zhuo Shi ³

Publication date (Electronic): May 2016

Journal: Thrombosis research

Publisher: Elsevier BV

Keywords: Aspirin, Endothelial cell, Panax notoginseng saponin, Platelet, Thrombogenesis

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Abstract

This study was designed to investigate the effect of Panax notoginseng saponin (PNS) on platelet adhesion to injured endothelial cells (ECs) and platelet activation induced by injured ECs, and to explore its underlying mechanisms.

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Journal ID (iso-abbrev): Thromb. Res.

Title: Thrombosis research

Publisher: Elsevier BV

ISSN (Electronic): 1879-2472

ISSN (Print): 0049-3848

Publication date (Electronic): May 2016

Volume: 141

Affiliations

[1 ] Center for Cardiovascular Disease, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.

[2 ] Beijing University of Chinese Medicine, Beijing 100029, China.

[3 ] Center for Cardiovascular Disease, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China. Electronic address: dz_shi@163.com.

Article

Publisher Item ID: S0049-3848(16)30082-2

DOI: 10.1016/j.thromres.2016.03.022

PubMed ID: 27043068

SO-VID: d4853802-9eb4-4ff6-8e10-0b4c961a4bca

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Keywords: Endothelial cell,Panax notoginseng saponin,Platelet,Thrombogenesis,Aspirin

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Keywords: Endothelial cell, Panax notoginseng saponin, Platelet, Thrombogenesis, Aspirin

Panax notoginseng saponin is superior to aspirin in inhibiting platelet adhesion to injured endothelial cells through COX pathway in vitro.

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