+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Effect of Ovariectomy on Plasma LH, FSH, Estradiol, and Progesterone and Medial Basal Hypothalamic LHRH Concentrations in Old and Young Rats



      S. Karger AG

      Aging, LHRH, LH, FSH, Estradiol, Progesterone, Ovariectomy

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          Resting plasma concentrations of LH, FSH, estradiol, and progesterone and medial basal hypothalamic concentrations of LHRH (MBH-LHRH) were measured by RIA in 8- to 12-month-old female rats which had begun to exhibit constant estrous (CE) or prolonged diestrous (PD) vaginal smear patterns and compared to young cycling rats on proestrus, estrus, or diestrus. In addition, we examined the effect of ovariectomy on these hormonal profiles. Old CE rats have normal plasma LH, FSH and progesterone concentrations, but exhibit elevated estradiol levels and decreased MBH-LHRH concentrations compared to young cycling rats on the day of estrus. Ovariectomy results in an attenuated rise in plasma LH and FSH and a much lesser decrease in MBH-LHRH when compared to young rats, despite comparable steroid changes. Old PD rats have normal LH and FSH levels, but have elevated estradiol and progesterone concentrations and decreased MBH-LHRH levels when compared to young rats on the day of diestrus. Ovariectomy causes a normal decrease in MBH-LHRH; however, the increased gonadotropin levels are significantly less than seen in young controls.

          Related collections

          Author and article information

          S. Karger AG
          26 March 2008
          : 30
          : 1
          : 15-19
          Department of Physiology, School of Medicine, University of Maryland, Baltimore, Md., and Department of Physiology, School of Medicine, University of New Mexico, Albuquerque, N. Mex.
          122968 Neuroendocrinology 1980;30:15–19
          © 1980 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Original Paper


          Comment on this article