Introduction / objectives
This research was carried out to determine most important risk factors in the development
of MRSA by comparing infections due to methicillin resistant and susceptible strains
to make suggestions to decrease MRSA ratios by pointing out the importance of pre-infection
antibiotic usage in the development of MRSA infection and its place among the other
risk factors.
Methods
This research was planned as a retrospective case control study and possible risk
factors among inpatients owing to S. aureus infection at our hospital between 2003-2008
years, were compared as MRSA and MSSA groups.
Results
Hospitalization period, previous hospitalization existence and number, lining in intensive
care unit, MRSA existence in the same unit, polymicrobial infection, acute trauma,
surgery, open lesion, any intravenous, urethral catheter, mechanical ventilation,
invasive device number, previous antibiotic usage, number and period of used antibiotic
were found more significant in MRSA patients(p<0,05).Respectively, flouroquinolone
usage (OR, 2,56; %95 CI: 1,052–6,231; p<0,05), the time period of previous antibiotic
use (OR, 2,343; %95 CI: 1,697–3,236; p<0,05), hospitalization times (OR, 1,396; %95
CI: 1,235–1,578; p<0,05), previous hospitalization period (OR, 0,992; %95 CI: 0,986–0,999;
p<0,05), MRSA existence in the same milieu (OR, 0,283; %95 CI: 0,13–0,618; p<0,05)
were determined as independent risk factors in the development of infections due to
MRSA.
Conclusion
Controlling these risk factors and either avoiding uncontrolled prescription or decreasing
the use of selected antibiotic subcategories like flouroquinolones and cephalosporins
seem to reduce infection due to MRSA.
Disclosure of interest
None declared.