Kang Qi: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: SoftwareRole: Writing – original draftRole: Writing – review & editing
Xiangdong Li: Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
ResourcesRole: SoftwareRole: VisualizationRole: Writing – review & editing
Yongjian Geng: Role: ConceptualizationRole: SoftwareRole: Writing – review & editing
Hehe Cui: Role: ConceptualizationRole: Data curationRole: InvestigationRole: MethodologyRole:
ResourcesRole: Software
Chen Jin: Role: ConceptualizationRole: ResourcesRole: SoftwareRole: Writing – review & editing
Peihe Wang: Role: InvestigationRole: MethodologyRole: ResourcesRole: Software
Yue Li: Role: InvestigationRole: MethodologyRole: ResourcesRole: Software
Yuejin Yang: Role: ConceptualizationRole: Funding acquisitionRole: Project administrationRole:
ResourcesRole: SupervisionRole: ValidationRole: VisualizationRole: Writing – review
& editing
Qun Chen: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
18
June
2018
Publication date Collection: 2018
Volume: 13
Issue: 6
Electronic Location Identifier: e0198403
Affiliations
[1
]
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for
Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical
College, Beijing, China
[2
]
Division of Cardiovascular Medicine, University of Texas Health Science Center at
Houston, Houston, TX, United States of America
[3
]
Peking Key Laboratory for Pre-clinical Evaluation of Cardiovascular Implant Material,
State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular
Diseases, Animal Experimental Center, Fuwai Hospital, Chinese Academy of Medical Sciences
and Peking Union Medical College, Beijing, China
Virginia Commonwealth University Department of Internal Medicine, UNITED STATES
Author notes
Competing Interests: The authors have declared that no competing interests exist.
Article
Publisher ID:
PONE-D-18-01997
DOI: 10.1371/journal.pone.0198403
PMC ID: 6005559
PubMed ID: 29912977
SO-VID: d794db49-5e9e-446a-972e-dc0b7a9d02d8
Copyright © © 2018 Qi et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: National Basic Research Program (973 Program) in China
Award ID: 2012CB518602
Award Recipient
:
Yuejin Yang
Funded by: CAMS Innovation Fund for Medical Sciences (CIFMS)
Award ID: 2016-I2M-1-009
Award Recipient
:
Yuejin Yang
Funded by: National Science Foundation of China
Award ID: 81370223
Award Recipient
:
Yuejin Yang
Funded by: National Science Foundation of China
Award ID: 81573957
Award Recipient
:
Yuejin Yang
This study was supported by National Basic Research Program (973 Program) in China
(No. 2012CB518602), CAMS Innovation Fund for Medical Sciences (CIFMS) (No. 2016-I2M-1-009),
the National Science Foundation of China (No. 81370223 and 81573957) and Postgraduates’
Innovative Foundation of PUMC, China (2013-1002-39).
Subject:
Research Article
Subject:
Medicine and Health Sciences
Subject:
Endocrinology
Subject:
Endocrine Disorders
Subject:
Diabetes Mellitus
Subject:
Medicine and Health Sciences
Subject:
Metabolic Disorders
Subject:
Diabetes Mellitus
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Cardiovascular Anatomy
Subject:
Heart
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Cardiovascular Anatomy
Subject:
Heart
Subject:
Biology and life sciences
Subject:
Genetics
Subject:
Gene expression
Subject:
Gene regulation
Subject:
Small interfering RNAs
Subject:
Biology and life sciences
Subject:
Biochemistry
Subject:
Nucleic acids
Subject:
RNA
Subject:
Non-coding RNA
Subject:
Small interfering RNAs
Subject:
Medicine and Health Sciences
Subject:
Endocrinology
Subject:
Diabetic Endocrinology
Subject:
Insulin
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Hormones
Subject:
Insulin
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cell Processes
Subject:
Cell Death
Subject:
Apoptosis
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Epithelial Cells
Subject:
Endothelial Cells
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Epithelium
Subject:
Epithelial Cells
Subject:
Endothelial Cells
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Epithelium
Subject:
Epithelial Cells
Subject:
Endothelial Cells
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Sugar
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Sugar
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Sugar
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Sugar
Subject:
Medicine and Health Sciences
Subject:
Diagnostic Medicine
Subject:
Signs and Symptoms
Subject:
Necrosis
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Signs and Symptoms
Subject:
Necrosis
