Interrelationship of Time of Dialysis-Dependent Uremia and Pretransplant Blood Transfusions

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Abstract

In a consecutive series of 167 renal allotransplants, a statistically significant correlation was found between the number of pretransplant blood transfusions and the time of dialysis-dependent uremia. This correlation suggests that one possible explanation for the association of a beneficial effect of pretransplant blood transfusions with allograft survival may be in part due to the prolongation of uremia, which is a well-known immunosuppressive factor. This begs the question of whether the transfusion-dialysis time association promotes a further selection factor leaving sensitized patients waiting for longer periods of time for transplants or unable to receive transplants at all. Whether the transfusion and the favorable prognosis association is also related to other specific immunological mechanisms remains to be proven.

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Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISBN: 978-3-8055-2981-5

ISBN: 978-3-318-02025-0

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1978

Publication date (Print): 1978

Publication date (Electronic): 02 December 2008

Volume: 22

Issue: 1-3

Pages: 196-200

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Royal Victoria Hospital and McGill University, Montreal, P.Q.

Article

Publisher ID: 181448 Other ID: Nephron 1978;22:196–200

DOI: 10.1159/000181448

PubMed ID: 370626

SO-VID: d81ee950-1fd7-4d9a-981b-2925db01c923

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Interrelationship of Time of Dialysis-Dependent Uremia and Pretransplant Blood Transfusions

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Karger: Nephrology

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