Contributors
Masakazu Sugiyama: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: VisualizationRole: Writing – original draftRole: Writing – review
& editing
Akihiro Kikuchi: Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
VisualizationRole: Writing – original draftRole: Writing – review & editing
Hirofumi Misu: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: ResourcesRole: ValidationRole: Writing – review & editing
Hirobumi Igawa: Role: Investigation
Motooki Ashihara: Role: InvestigationRole: Methodology
Youichi Kushima: Role: InvestigationRole: Methodology
Kiyofumi Honda: Role: ConceptualizationRole: InvestigationRole: Methodology
Yoshiyuki Suzuki: Role: InvestigationRole: MethodologyRole: Writing – review & editing
Yoshiki Kawabe: Role: InvestigationRole: Methodology
Shuichi Kaneko: Role: Funding acquisitionRole: Project administrationRole: Supervision
Toshinari Takamura: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
MethodologyRole: Project administrationRole: ResourcesRole: SupervisionRole: ValidationRole:
Writing – review & editing
Hervé Guillou: Role: Editor
Journal
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
29
March
2018
Publication date Collection: 2018
Volume: 13
Issue: 3
Electronic Location Identifier: e0194798
Affiliations
[1
]
Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan
[2
]
Department of Endocrinology and Metabolism, Kanazawa University Graduate School of
Medical Sciences, Kanazawa, Ishikawa, Japan
[3
]
Department of System Biology, Kanazawa University Graduate School of Medical Sciences,
Kanazawa, Ishikawa, Japan
[4
]
PRESTO, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
Author notes
Competing Interests: TT has received a grant support from Chugai Pharmaceutical Co, Ltd. Co-authors MS,
MA, Y. Kushima, KH, YS, and Y. Kawabe are employed by Chugai Pharmaceutical Co, Ltd.
There are no competing interests to declare for any of the other authors. These affiliations
do not alter the authors' adherence to PLOS ONE policies on sharing data and materials.
Article
Publisher ID:
PONE-D-17-34157
DOI: 10.1371/journal.pone.0194798
PMC ID: 5875797
PubMed ID: 29596463
SO-VID: d8977d4b-4b4e-4fe6-82e6-492d8426601b
Copyright © © 2018 Sugiyama et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
History
Date
received
: 20
September
2017
Date
accepted
: 11
February
2018
Page count
Figures: 6,
Tables: 1,
Pages: 20
Funding
This work was supported by the Chugai Pharmaceutical Co., Ltd. The Chugai Pharmaceutical
Co. Ltd. provided support in the form of salaries for authors MS, MA, Y. Kushima,
KH, YS, and Y. Kawabe. TT received research grants from Chugai Pharmaceutical Co.,
Ltd. There are no products currently being developed or already in the market that
are associated with this research. The funder provided support in the form of salaries
for authors MS, MA, Y. Kushima, KH, YS, and Y. Kawabe as Chugai’s employees. The authors
from the funder designed the study, collected the data and analyzed data for the animal
studies. And these authors also contributed to analyze DNA chip and prepare the manuscript.
The specific roles of these authors are shown in the ‘author contributions’ section.
Categories
Subject:
Research Article
Subject:
Biology and life sciences
Subject:
Genetics
Subject:
Gene expression
Subject:
Gene regulation
Subject:
Small interfering RNAs
Subject:
Biology and life sciences
Subject:
Biochemistry
Subject:
Nucleic acids
Subject:
RNA
Subject:
Non-coding RNA
Subject:
Small interfering RNAs
Subject:
Research and Analysis Methods
Subject:
Experimental Organism Systems
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Experimental Organism Systems
Subject:
Animal Models
Subject:
Mouse Models
Subject:
Medicine and Health Sciences
Subject:
Endocrinology
Subject:
Endocrine Physiology
Subject:
Insulin Resistance
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Endocrine Physiology
Subject:
Insulin Resistance
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Endocrine Physiology
Subject:
Insulin Resistance
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Gene Expression
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Physiological Parameters
Subject:
Body Weight
Subject:
Obesity
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Physiological Parameters
Subject:
Body Weight
Subject:
Obesity
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Adipose Tissue
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Adipose Tissue
Subject:
Medicine and Health Sciences
Subject:
Endocrinology
Subject:
Diabetic Endocrinology
Subject:
Insulin
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Hormones
Subject:
Insulin
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Lipids
Subject:
Fats
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