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      Resolution of macular edema in Coats' disease with intravitreal bevacizumab

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          A 13-year-old boy was referred because of visual deterioration in his right eye. The visual acuity was two meters of counting fingers. Indirect ophthalmoscopy and biomicroscopy revealed exudative macular edema as well as tumor-like telangiectatic vessels and exudation in temporal periphery. With diagnosis of Coats' disease (stage II) confirmed by fluorescein angiography, three intravitreal injections of bevacizumab were performed at 6-week intervals. One year after the last injection, there was a significant resolution of macular edema as well as visual acuity improvement to 20/20. This is the first case report in which a distinct improvement in macular edema was observed with intravitreal bevacizumab in Coats' disease.

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          Most cited references 6

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          Forms of retinal diseases with massive exudation

           G. Coats,  COATS (1908)
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            Resolution of severe macular oedema in adult Coat's syndrome with high-dose intravitreal triamcinolone acetonide.

            To report the clinical outcome of a patient who received high-dose intravitreal triamcinolone acetonide as treatment for severe macular oedema secondary to adult Coat's syndrome. Case report. A 74-year-old Indian man complaining of chronic gradual blurring of vision in the left eye was found to have adult Coat's syndrome with severe macular oedema. He received 25 mg of intravitreal triamcinolone acetonide following unsuccessful resolution with grid laser. Optical coherence tomography (OCT) demonstrated up to 75% decrease in macular oedema that was evident even after 9 months follow-up. However, there was no significant improvement in visual acuity. Intravitreal triamcinolone is a reasonable option in reducing severe macular oedema in cases of adult Coat's syndrome.
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              Premacular fibrosis in juvenile Coats' disease with spontaneous peeling after photocoagulation of the congenital vascular anomalies

               BA Lefaut,  H Priem,  JJ Laey (1996)

                Author and article information

                Indian J Ophthalmol
                Indian Journal of Ophthalmology
                Medknow Publications (India )
                Jan-Feb 2010
                : 58
                : 1
                : 80-82
                Department of Opthomology, Ophthalmic Research Centre, Shahid Beheshti University (M.C.), Tehran, Iran
                Author notes
                Correspondence to: Dr. Morteza Entezari, Department of Ophthalmology, Imam Hossein Medical Center affiliated to Shahid Beheshti University (M.C.), Tehran, Iran. E-mail: morteza.entezari@ 123456gmail.com
                © Indian Journal of Ophthalmology

                This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                Brief Communications

                Ophthalmology & Optometry

                coats' disease, bevacizumab, macular edema


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