We derive explicit forms for the superisometries of a wide class of supercoset manifolds,
including those with fermionic generators in the stability group. We apply the results
to construct the action of SU(2,2|4) on three supercoset manifolds: (10|32)-dimensional
AdS_5 x S^5 superspace, (4|16)-dimensional conformal superspace, and a novel (10|16)-dimensional
conformal superspace. Using superembedding techniques, we show, to lowest non-trivial
order in the fermions, that at the boundary of AdS_5, the superisometries of the AdS_5
x S^5$ superspace reduce to the standard N=4 superconformal transformations. In particular,
half of the 32 fermionic coordinates decouple from the superisometries.