Human epicardial adipose tissue induces fibrosis of the atrial myocardium through the secretion of adipo-fibrokines.

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Abstract

Recent studies have reported a relationship between the abundance of epicardial adipose tissue (EAT) and the risk of cardiovascular diseases including atrial fibrillation (AF). However, the underlying mechanisms are unknown. The aim of this study was to examine the effects of the secretome of human EAT on the histological properties of the myocardium.

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Journal

Journal ID (iso-abbrev): Eur. Heart J.

Title: European heart journal

ISSN (Electronic): 1522-9645

ISSN (Print): 0195-668X

Publication date (Electronic): Apr 1 2015

Volume: 36

Issue: 13

Affiliations

[1 ] Institute of Cardiometabolism and Nutrition, Paris, France INSERM, UMR_S 872, Team 7 Nutriomique, Paris, France Université Pierre et Marie Curie-Paris 6, Cordeliers Research Center, Paris, France.

[2 ] Institute of Cardiometabolism and Nutrition, Paris, France Université Pierre et Marie Curie-Paris 6, Cordeliers Research Center, Paris, France Université Pierre et Marie Curie-Paris 6, INSERM UMR_S956, Paris, France.

[3 ] Institute of Cardiometabolism and Nutrition, Paris, France INSERM, UMR_S 872, Team 7 Nutriomique, Paris, France Université Pierre et Marie Curie-Paris 6, Cordeliers Research Center, Paris, France Heart and metabolism division, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris Faculté de Médecine, INSERM NORT UMR 1062, INRA1260, Aix Marseille Université, Marseille, France.

[4 ] Institute of Cardiometabolism and Nutrition, Paris, France Heart and metabolism division, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris.

[5 ] Faculté de Médecine, INSERM NORT UMR 1062, INRA1260, Aix Marseille Université, Marseille, France.

[6 ] Institute of Cardiometabolism and Nutrition, Paris, France INSERM, UMR_S 872, Team 7 Nutriomique, Paris, France Université Pierre et Marie Curie-Paris 6, Cordeliers Research Center, Paris, France Heart and metabolism division, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris stephane.hatem@upmc.fr karine.clement@psl.aphp.fr.

[7 ] Institute of Cardiometabolism and Nutrition, Paris, France Université Pierre et Marie Curie-Paris 6, Cordeliers Research Center, Paris, France Université Pierre et Marie Curie-Paris 6, INSERM UMR_S956, Paris, France Heart and metabolism division, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris stephane.hatem@upmc.fr karine.clement@psl.aphp.fr.

Article

Publisher Item ID: eht099

DOI: 10.1093/eurheartj/eht099

PubMed ID: 23525094

SO-VID: d96bc57f-a4de-4616-a2c6-b3e5a1d46eac

History

Keywords: Activin A,Atrial fibrillation,Atrial fibrosis,Epicardial adipose tissue,Myocardial fibrosis

Data availability:

Keywords: Activin A, Atrial fibrillation, Atrial fibrosis, Epicardial adipose tissue, Myocardial fibrosis

Human epicardial adipose tissue induces fibrosis of the atrial myocardium through the secretion of adipo-fibrokines.

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Karger: Cardiovascular System

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