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      Reference intervals of anti‐Müllerian hormone in Korean women

      brief-report

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          Abstract

          Background

          Limited data are available with reference intervals of serum anti‐Müllerian hormone (AMH) level in Korean women.

          Methods

          We retrospectively reviewed serum AMH test results performed with automated electrochemiluminescence immunoassay in Korean women who visited health promotion centers between January 2019 and December 2020. Serum AMH results by age group were compared with previously reported reference intervals.

          Results

          During the 2‐year study period, a total of 1953 AMH test results from Korean women (age 20–49 years) undergoing general health checkups were obtained. Serum AMH level differed significantly by age group. Peak AMH level was observed at age 25–29 years and decreased to undetectable for subjects older than 44 years. The 2.5th, 5th, and 10th percentile values of the present study were comparable with previously assessed lower limits of reference intervals. The upper limit of the reference interval defined as the 97.5th percentile value in women younger than 35 years was higher than that of Western populations. The 90th percentile value of the present study population was similar to the 95th or 97.5th percentile value of reference intervals for Western populations of women younger than 35 years.

          Conclusion

          Understanding patient populations and differences in reference intervals by age group and measurement method can help guide clinical decisions and clinical laboratory analysis.

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          Most cited references14

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          Anti-Müllerian Hormone and Ovarian Reserve: Update on Assessing Ovarian Function

          Loes M E Moolhuijsen, Jenny Visser (2020)
          Abstract Context Anti-müllerian hormone (AMH) is produced by granulosa cells of small, growing follicles in the ovary. Serum AMH levels strongly correlate with the number of growing follicles, and therefore AMH has received increasing attention as a marker for ovarian reserve. This review summarizes recent findings and limitations in the application of serum AMH in ovarian reserve assessment. Evidence Acquisition A PubMed search was conducted to find recent literature on the measurements and use of serum AMH as a marker for ovarian reserve. Evidence Synthesis Serum AMH levels are measured to assess the “functional ovarian reserve,” a term that is preferred over “ovarian reserve,” since AMH levels reflect the pool of growing follicles that potentially can ovulate. Serum AMH levels are used in individualized follicle-stimulating hormone dosing protocols and may predict the risk of poor response or ovarian hyperstimulation syndrome but has limited value in predicting ongoing pregnancy. Serum AMH levels are studied to predict natural or disease-related age of menopause. Studies show that the age-dependent decline rates of AMH vary among women. The generalized implementation of serum AMH measurement has also led to an increase in diagnostic assays, including automated assays. However, direct comparison of results remains problematic. Conclusion Serum AMH remains the preferred ovarian reserve marker. However, the lack of an international standard for AMH limits comparison between AMH assays. Furthermore, little is known about endogenous and exogenous factors that influence serum AMH levels, which limits proper interpretation of AMH values in a clinical setting.
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            Multicenter analytical performance evaluation of a fully automated anti-Müllerian hormone assay and reference interval determination.

            E Anckaert, M A Oktem, A Thies … (2016)
            Anti-Müllenria hormone (AMH) is an established biomarker for assessing ovarian reserve and predicting response to controlled ovarian stimulation. Its routine clinical use is hampered by the variability and low-throughput of available enzyme-linked immunosorbent assays (ELISA). The presented study examined if a fully automated AMH electrochemiluminescence assay (ECLIA; Elecsys® AMH assay, Roche Diagnostics) was suitable for measuring AMH levels in healthy women and in those diagnosed with polycystic ovary syndrome (PCOS).
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              Age specific serum anti-Müllerian hormone levels in 1,298 Korean women with regular menstruation

              Ji Hee Yoo, Hye Kim, Sun Wha Cha … (2011)
              Objective To determine the age specific serum anti-Müllerian hormone (AMH) reference values in Korean women with regular menstruation. Methods Between May, 2010 and January, 2011, the serum AMH levels were evaluated in a total of 1,298 women who have regular menstrual cycles aged between 20 and 50 years. Women were classified into 6 categories by age: 20-31 years, 32-34 years, 35-37 years, 38-40 years, 41-43 years, above 43 years. Measurement of serum AMH was measured by commercial enzyme-linked immunoassay. Results The serum AMH levels correlated negatively with age. The median AMH level of each age group was 4.20 ng/mL, 3.70 ng/mL, 2.60 ng/mL, 1.50 ng/mL, 1.30 ng/mL, and 0.60 ng/mL, respectively. The AMH values in the lower 5th percentile of each age group were 1.19 ng/mL, 0.60 ng/mL, 0.42 ng/mL, 0.27 ng/mL, 0.14 ng/mL, and 0.10 ng/mL, respectively. Conclusion This study determined reference values of serum AMH in Korean women with regular menstruation. These values can be applied to clinical evaluation and treatment of infertile women.
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                Author and article information

                Contributors
                Sang Gon Lee: sglee@gclabs.co.kr
                Eun Hee Lee: ehlee@gclabs.co.kr
                Journal
                Journal ID (nlm-ta): J Clin Lab Anal
                Journal ID (iso-abbrev): J Clin Lab Anal
                Journal ID (doi): 10.1002/(ISSN)1098-2825
                Journal ID (publisher-id): JCLA
                Title: Journal of Clinical Laboratory Analysis
                Publisher: John Wiley and Sons Inc. (Hoboken )
                ISSN (Print): 0887-8013
                ISSN (Electronic): 1098-2825
                Publication date (Electronic): 19 July 2022
                Publication date Collection: September 2022
                Volume: 36
                Issue: 9 ( doiID: 10.1002/jcla.v36.9 )
                Electronic Location Identifier: e24525
                Affiliations
                [ 1 ] Department of Laboratory Medicine Green Cross Laboratories Yongin Korea
                [ 2 ] Department of Laboratory Medicine and Genetics, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea
                [ 3 ] Green Cross Laboratories Yongin Korea
                Author notes
                [*] [* ] Correspondence

                Sang Gon Lee, Department of Laboratory Medicine, Green Cross Laboratories, Yongin, Gyeonggi 16924, Korea.

                Email: sglee@ 123456gclabs.co.kr

                Eun Hee Lee, Green Cross Laboratories, Yongin, Gyeonggi 16924, Korea.

                Email: ehlee@ 123456gclabs.co.kr

                Author information
                https://orcid.org/0000-0002-8266-2248
                Article
                Publisher ID: JCLA24525 Other ID: JCLA-22-1207.R1
                DOI: 10.1002/jcla.24525
                PMC ID: 9459265
                PubMed ID: 35853089
                SO-VID: dac17d05-d71a-46c8-8582-e267fcf30bd7
                Copyright © © 2022 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC.
                License:

                This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                Date revision received : 09 May 2022
                Date received : 15 April 2022
                Date accepted : 15 May 2022
                Page count
                Figures: 2, Tables: 1, Pages: 5, Words: 2601
                Categories
                Subject: Brief Report
                Subject: Brief Report
                Custom metadata
                source-schema-version-number 2.0
                cover-date September 2022
                details-of-publishers-convertor Converter:WILEY_ML3GV2_TO_JATSPMC version:6.1.8 mode:remove_FC converted:09.09.2022

                ScienceOpen disciplines: Clinical chemistry
                Keywords: anti‐müllerian hormone,health checkup,korea,ovarian reserve,reference interval
                Data availability:
                ScienceOpen disciplines: Clinical chemistry
                Keywords: anti‐müllerian hormone, health checkup, korea, ovarian reserve, reference interval

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