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      Flow diverter embolization device for endovascular treatment of ruptured blister and wide necked very small aneurysms

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          Abstract

          Purpose

          Ruptured blood blisters (BBA) and very small, wide necked aneurysms (VSA) remain challenging lesions to treat due to their small size, wide necks, and thin, fragile walls. In the present study, we reviewed our experience with these aneurysms treated by flow diversion.

          Methods

          A total of 18 patients with hemorrhage due to a ruptured BBAs and VSAs, treated with flow diversion between July 2014 and March 2016 were included in this study. We analyzed clinical and radiographic outcomes.

          Results

          A total of 12 (66.7%) VSAs and 6 (33.3%) BBAs were treated with flow diversion. Fifteen (83.3%) and three (16.7%) aneurysms were located on the internal carotid artery and the basilar artery, respectively. On admission, a GCS score of 15 and WFNS grade 1 were found in 14 (77.7%) patients, 3 patients had an admission GCS of 13 and WFNS grade 2, one had an admission GCS of 8 and WFNS of 4. Fisher CT grades 2, 3, and 4 were observed in 11 (61.1%), 1 (5.6%), and 6 (33.3%) patients, respectively. Flow diversion was performed on average 5.6 days after onset of hemorrhage. 6 months post-intervention angiography showed complete obliteration of the aneurysms in all patients.

          Conclusion

          Our findings indicate that flow diversion in the acute and subacute phase of hemorrhage is a reliable treatment for reducing complications in patients with BBAs and VSAs. In patients with poor clinical presentation it might be reasonable to delay treatment until the first signs of recovery become apparent.

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          Risk of ventriculostomy-related hemorrhage in patients with acutely ruptured aneurysms treated using stent-assisted coiling.

          Intracranial stenting has improved the ability to treat wide-neck aneurysms via endovascular techniques. However, stent placement necessitates the use of antiplatelet agents, and the latter may complicate the treatment of patients with acutely ruptured aneurysms who demonstrate hydrocephalus and require ventriculostomy. Antiplatelet agents in this setting could increase the incidence of ventriculostomy-related hemorrhagic complications, but there are insufficient data in the medical literature to quantify this potential risk. The aim of this study was to directly quantify the risk of ventriculostomy-related hemorrhage in patients with acute aneurysmal subarachnoid hemorrhage treated with stent-assisted coiling. The authors retrospectively identified 131 patients who underwent endovascular treatment for an acutely ruptured aneurysm as well as ventriculostomy or ventriculoperitoneal (VP) shunt placement. The rate of hemorrhagic complications associated with ventriculostomy or VP shunt insertion was compared between patients who underwent coiling without a stent (Group 1) and those who underwent stent-assisted coiling and dual antiplatelet therapy (Group 2). One hundred nine ventriculostomies or VP shunt placement procedures were performed in 91 patients in Group 1, and 50 procedures were undertaken in 40 patients in Group 2. The rates of radiographic hemorrhage and symptomatic hemorrhage were significantly higher in Group 2 (32% vs 14.7%, p = 0.02; and 8% vs 0.9%, p = 0.03, respectively). On multivariate analyses, Group 2 had 3.42 times the odds of a radiographic hemorrhage (95% CI 1.46-8.04, p = 0.0048) after adjusting for antiplatelet use prior to admission. The application of dual antiplatelet therapy in stent-assisted coiling of acutely ruptured aneurysms is associated with an increase in the risk of hemorrhagic complications following ventriculostomy or VP shunt placement, as compared with its use in a coiling procedure without a stent.
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            Endovascular Treatment of Ruptured Blister-Like Aneurysms: A Systematic Review and Meta-Analysis with Focus on Deconstructive versus Reconstructive and Flow-Diverter Treatments.

            Various endovascular techniques have been applied to treat blister-like aneurysms. We performed a systematic review to evaluate endovascular treatment for ruptured blister-like aneurysms.
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              Flow diverter stents in the treatment of intracranial aneurysms: Where are we?

              Flow diverter stents are devices designed to treat complex aneurysms. According to preliminary series published in the literature, treatment of aneurysms with flow diverters is highly efficacious with acceptable morbidity and mortality. Delayed aneurysm ruptures have been reported but mechanisms are actually not completely elucidated. In-stent thrombosis or stenosis was also observed. Indications of flow diverters are complex aneurysms (fusiform, large and giant, wide neck, small aneurysms untreatable by conventional coiling) as well as recurrences. Several randomized studies and registries are actually in progress and will contribute to a more precise knowledge of the place of the flow diverters in the treatment of intracranial aneurysms. Copyright © 2011 Elsevier Masson SAS. All rights reserved.
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                Author and article information

                Contributors
                Journal
                Heliyon
                Heliyon
                Heliyon
                Elsevier
                2405-8440
                13 September 2019
                September 2019
                13 September 2019
                : 5
                : 9
                : e02241
                Affiliations
                [a ]Division of Vascular and Endovascular Neurosurgery, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
                [b ]Department of Neurosurgery, Geisinger Health System, Danville, PA, USA
                [c ]Research Institute of Neurointervention, Paracelsus Medical University, Salzburg, Austria
                [d ]Department of Neurological Surgery, Weill Cornell Medicine, New York, NY, USA
                [e ]Department of Neurosurgery, School of Medicine, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
                [f ]Razi Hospital, Tehran University of Medical Sciences, Iran
                Author notes
                []Corresponding author. ghorbani.m@ 123456iums.ac.ir
                Article
                S2405-8440(19)35901-8 e02241
                10.1016/j.heliyon.2019.e02241
                6819851
                daddb19d-80a2-4d49-850c-8d4ee7de8834
                © 2019 Published by Elsevier Ltd.

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                : 24 April 2019
                : 3 June 2019
                : 2 August 2019
                Categories
                Article

                neurology,surgery,medicine,neurosurgery,medical imaging,radiology,very small aneurysms,blood blister aneurysms,flow diverter devices

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