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Purification of Ethoxyquin and Its Two Oxidation Products
August 2000
August 2000
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Abstract
2,6-Dihydro-2,2,4-trimethyl-6-quinolone (QI) and 1,8'-bis(1, 2-dihydro-6-ethoxy-2,2,4-trimethylquinoline)
(DM) are two oxidation products of 1,2-dihydro-6-ethoxy-2,2,4-trimethylquinoline (ethoxyquin,
EQ). This paper describes several methods for the purification of technical grade
EQ and for the production of pure QI and DM as standards with the purity required
(>99%) for calibration of quantitative determination methods. EQ of high purity was
obtained through vacuum distillation followed by a quick column chromatographic purification
on silica gel. Preparative scale purity DM could be obtained through recrystallization
from methanol, but QI could be purified only by a high-pressure liquid chromatographic
method.