Prediction of cardiovascular risk in patients with familial hypercholesterolaemia.

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Abstract

Patients with familial hypercholesterolaemia (FH) have an elevated cardiovascular (CV) risk. The objective of this analysis was to adjust CV risk equations derived in non-FH populations with hyperlipidaemia to predict CV risk in FH patients, and then to use these adjusted CV risk equations in a decision analytic model in order to predict lifetime CV risk in FH patients.

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Journal

Journal ID (iso-abbrev): Eur Heart J Qual Care Clin Outcomes

Title: European heart journal. Quality of care & clinical outcomes

Publisher: Oxford University Press (OUP)

ISSN (Electronic): 2058-1742

ISSN (Print): 2058-1742

Publication date (Electronic): Oct 01 2017

Volume: 3

Issue: 4

Affiliations

[1 ] Economic Modeling, Center of Excellence, Amgen (Europe) GmbH, Dammstrasse 23, PO Box 1557, Zug, CH-6301, Switzerland.

[2 ] Centre for Clinical Epidemiology and Biostatistics, University of Pennsylvania, 423 Guardian Drive, Pennsylvania, PA 19104-6021, USA.

[3 ] Global Health Economics, Amgen [Europe] GmbH, Dammstrasse 23, PO Box 1557, CH-6301, Zug, Switzerland.

[4 ] School of Public Health Imperial College London, South Kensington Campus, London, SW7 2AZ, UK.

[5 ] Fundación Hipercolesterolemia Familiar, General ,varez de Castro, 14 1°E, Madrid, 28010 Spain.

[6 ] Endocrinology - Metabolism and Prevention of Cardiovascular Diseases, Hôpital Pitié Salpêtrière, 47-83 Boulevard de l'Hôpital, Paris, 75651, France.

Article

Publisher Item ID: 3858409

DOI: 10.1093/ehjqcco/qcx011

PubMed ID: 29044394

SO-VID: dc6d3946-6ac3-4758-a856-737f4511bd3b

History

Keywords: Lipid-modifying therapy,Cardiovascular disease,Risk prediction,Risk equations,Familial hypercholesterolaemia,Decision analytic models

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Keywords: Lipid-modifying therapy, Cardiovascular disease, Risk prediction, Risk equations, Familial hypercholesterolaemia, Decision analytic models

Prediction of cardiovascular risk in patients with familial hypercholesterolaemia.

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Cardiovascular Innovations and Applications

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