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Pathogenesis of Oxalate Urolithiasis: Lessons From Experimental Studies With Rats
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Abstract
Calcium oxalate (CaOx) urolithiasis in rats is induced by producing hyperoxaluria.
Depending on the degree and length of hyperoxaluria, CaOx crystals may either form
in the nephron or the bladder and may or may not be retained in the kidneys. Crystals
may nucleate in one part of the nephron and be retained in another part. Papillary
collecting duct tubular epithelium and its basement membrane appear to be involved
in crystal retention in the kidneys.