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      Enhanced secretion of endothelin-1 by elevated glucose levels from cultured bovine aortic endothelial cells.

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      Animals, Aorta, drug effects, metabolism, Cattle, Cells, Cultured, Chromatography, High Pressure Liquid, Endothelins, Endothelium, Glucose, pharmacology, Mannitol, Peptides, Phthalazines

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          Abstract

          We have investigated the effect of glucose on the release of endothelin-1-like immunoreactivity (ET-1-LI) from cultured bovine aortic endothelial cells. Elevation of glucose concentrations in cultured media from 5.5 to 11.1 or 22.2 mM significantly stimulated ET-1-LI release from cultured endothelial cells. An aldose reductase inhibitor did not affect the high glucose-induced ET-1-LI release. These findings suggest the possibility that hyperglycemia in diabetic patients enhances ET-1-LI release at the local site of vascular endothelium, which might be involved in the developments of vascular complications and atherosclerosis.

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