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<p class="first" id="P3">Targeted pulmonary delivery facilitates the direct application
of bioactive materials
to the lungs in a controlled manner and provides an exciting platform for targeting
magnetic nanoparticles (MNPs) to the lungs. Iron oxide MNPs remotely heat in the presence
of an alternating magnetic field (AMF) providing unique opportunities for therapeutic
applications such as hyperthermia. In this study, spray drying was used to formulate
magnetic nanocomposite microparticles (“MnMs”) consisting of iron oxide MNPs and D-mannitol.
The physicochemical properties of these MnMs were evaluated and the
<i>in vitro</i> aerosol dispersion performance of the dry powders was measured by
the Next Generation
Impactor®. For all powders the mass median aerosol diameter (MMAD) was < 5 µm and
deposition patterns revealed that MnMs could deposit throughout the lungs. Heating
studies with a custom AMF showed that MNPs retain excellent thermal properties after
spray drying into composite dry powders, with specific absorption ratios (SAR) >200
<i>in vitro</i> studies on a human lung cell line indicated moderate cytotoxicity
of these materials.
These inhalable composites present a class of materials with many potential applications
and pose a promising approach for thermal treatment of the lungs through targeted
pulmonary administration of MNPs.