Studies on MIP-2 and CXCR2 expression in a mouse model of extrahepatic colorectal metastasis.

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Abstract

The CXC chemokine macrophage inflammatory protein (MIP)-2 has been shown to promote outgrowth of colorectal liver metastasis by enhancing angiogenesis and tumor cell migration. However, the effect of MIP-2 on extrahepatic metastasis is not known yet. With a use of a murine model, we therefore studied cell proliferation and microvascularization of extrahepatic CT26.WT-GFP colorectal tumors after exposure to MIP-2.

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Journal

Journal ID (iso-abbrev): Eur J Surg Oncol

Title: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Publisher: Elsevier BV

ISSN: 0748-7983

ISSN (Print): 0748-7983

Publication date (Electronic): Aug 2007

Volume: 33

Issue: 6

Affiliations

[1 ] Department of General, Visceral, Vascular and Pediatric Surgery, University of Saarland, Kirrbergerstr., D-66421 Homburg/Saar, Germany. otto.kollmar@uniklinikum-saarland.de

Article

Publisher Item ID: S0748-7983(07)00027-3

DOI: 10.1016/j.ejso.2007.01.012

PubMed ID: 17314027

SO-VID: e0ec1f6c-d5b8-4350-9d32-d9d8f69e40a5

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