- Record: found
- Abstract: found
- Article: found
SARS-Cov2 acute and post-active infection in the context of autoimmune and chronic inflammatory diseases
research-article
Regina Larionova
a
,
b ,
K. Byvaltsev
c ,
Оlga Kravtsova
b ,
Elena Takha
a ,
Sergei Petrov
a
,
d ,
Gevorg Kazarian
a ,
Anna Valeeva
a ,
Eduard Shuralev
a
,
d
,
e ,
Malik Mukminov
a
,
d ,
Yves Renaudineau
a
,
f
,
∗ ,
Marina Arleevskaya
a
,
b
12 April 2022
SARS-Cov2,
Infection,
Rheumatoid arthritis,
Systemic lupus erythematosus,
Risk factors,
Inflammation,
ACE2, angiotensin converting enzyme 2,
ACPA, anti-cyclic citrullinated peptide autoAb,
ANA, antinuclear autoAb,
aPL, antiphospholipid,
AutoAb, autoantibodies,
BAFF/BlySS, B-cell-activating factor/B lymphocyte stimulator,
CCL, chemokine ligand,
COVID-19, coronavirus disease 2019,
DMARDs, disease-modifying anti-rheumatic drugs,
E, envelope,
HEp-2, human epithelioma cell line 2,
IFN-I, interferon type I,
IFNAR, IFN-alpha receptors,
Ig, immunoglobulin,
IL, interleukin,
IRF, interferon regulatory factor,
ISGs, IFN-stimulated genes,
ITP, immune-thrombocytopenic purpura,
Jak, Janus kinase,
LDH, lactate dehydrogenase,
M, membrane,
mAb, monoclonal Ab,
MDA-5, melanoma differentiation-associated protein,
MERS-Cov, Middle East respiratory syndrome coronavirus,
MIS-C, multisystem inflammatory syndrome in children,
N, nucleocapsid,
NET, nuclear extracellular traps,
NF-κB, nuclear factor-kappa B,
NK, natural killer,
NLRP3, NOD-like receptor family,
pyrin domain containing 3, ORF,
open reading frame, PACS,
post-active COVID-19 syndrome, PAD-4,
peptidylarginine deiminase 4, PAMPs,
pathogen-associated molecular patterns, pDC,
plasmacytoid dendritic cells, PMN,
polymorphonuclear leukocytes, PRRs,
pattern recognition receptors, RA,
rheumatoid arthritis, RBD,
receptor binding domain, RF,
rheumatoid factor, RIG-I,
retinoic acid-inducible gene I, ROS,
reactive oxygen species, rt-PCR,
reverse transcription polymerase chain reaction, S,
spike, SAD,
systemic autoimmune disease, SARS-Cov2,
severe acute respiratory coronavirus 2, SjS,
primary Sjögren's syndrome, SLE,
systemic lupus erythematosus, SSc,
systemic sclerosis, ssRNA,
single-stranded ribonucleic acid, STAT,
signal transducer and activator of transcription, TCR,
T cell receptor, TLR,
Toll-like receptor, TMPRSS2,
transmembrane serine protease 2, TNF,
tumor necrosis factor, Treg,
regulatory T cells, VDJ,
variable, diversity and joining Ig genes
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Abstract
The clinical and immunological spectrum of acute and post-active COVID-19 syndrome overlaps with criteria used to characterize autoimmune diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Indeed, following SARS-Cov2 infection, the innate immune response is altered with an initial delayed production of interferon type I (IFN–I), while the NF-kappa B and inflammasome pathways are activated. In lung and digestive tissues, an alternative and extrafollicular immune response against SARS-Cov2 takes place with, consequently, an altered humoral and memory T cell response leading to breakdown of tolerance with the emergence of autoantibodies. However, the risk of developing severe COVID-19 among SLE and RA patients did not exceed the general population except in those having pre-existing neutralizing autoantibodies against IFN-I. Treatment discontinuation rather than COVID-19 infection or vaccination increases the risk of developing flares. Last but not least, a limited number of case reports of individuals having developed SLE or RA following COVID-19 infection/vaccination have been reported. Altogether, the SARS-Cov2 pandemic represents an unique opportunity to investigate the dangerous interplay between the immune response against infectious agents and autoimmunity, and to better understand the triggering role of infection as a risk factor in autoimmune and chronic inflammatory disease development.
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Most cited references142
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Author and article information
sars-cov2,infection,rheumatoid arthritis,systemic lupus erythematosus,risk factors,inflammation,ace2, angiotensin converting enzyme 2,acpa, anti-cyclic citrullinated peptide autoab,ana, antinuclear autoab,apl, antiphospholipid,autoab, autoantibodies,baff/blyss, b-cell-activating factor/b lymphocyte stimulator,ccl, chemokine ligand,covid-19, coronavirus disease 2019,dmards, disease-modifying anti-rheumatic drugs,e, envelope,hep-2, human epithelioma cell line 2,ifn-i, interferon type i,ifnar, ifn-alpha receptors,ig, immunoglobulin,il, interleukin,irf, interferon regulatory factor,isgs, ifn-stimulated genes,itp, immune-thrombocytopenic purpura,jak, janus kinase,ldh, lactate dehydrogenase,m, membrane,mab, monoclonal ab,mda-5, melanoma differentiation-associated protein,mers-cov, middle east respiratory syndrome coronavirus,mis-c, multisystem inflammatory syndrome in children,n, nucleocapsid,net, nuclear extracellular traps,nf-κb, nuclear factor-kappa b,nk, natural killer,nlrp3, nod-like receptor family,pyrin domain containing 3, orf,open reading frame, pacs,post-active covid-19 syndrome, pad-4,peptidylarginine deiminase 4, pamps,pathogen-associated molecular patterns, pdc,plasmacytoid dendritic cells, pmn,polymorphonuclear leukocytes, prrs,pattern recognition receptors, ra,rheumatoid arthritis, rbd,receptor binding domain, rf,rheumatoid factor, rig-i,retinoic acid-inducible gene i, ros,reactive oxygen species, rt-pcr,reverse transcription polymerase chain reaction, s,spike, sad,systemic autoimmune disease, sars-cov2,severe acute respiratory coronavirus 2, sjs,primary sjögren's syndrome, sle,systemic lupus erythematosus, ssc,systemic sclerosis, ssrna,single-stranded ribonucleic acid, stat,signal transducer and activator of transcription, tcr,t cell receptor, tlr,toll-like receptor, tmprss2,transmembrane serine protease 2, tnf,tumor necrosis factor, treg,regulatory t cells, vdj,variable, diversity and joining ig genes
sars-cov2, infection, rheumatoid arthritis, systemic lupus erythematosus, risk factors, inflammation, ace2, angiotensin converting enzyme 2, acpa, anti-cyclic citrullinated peptide autoab, ana, antinuclear autoab, apl, antiphospholipid, autoab, autoantibodies, baff/blyss, b-cell-activating factor/b lymphocyte stimulator, ccl, chemokine ligand, covid-19, coronavirus disease 2019, dmards, disease-modifying anti-rheumatic drugs, e, envelope, hep-2, human epithelioma cell line 2, ifn-i, interferon type i, ifnar, ifn-alpha receptors, ig, immunoglobulin, il, interleukin, irf, interferon regulatory factor, isgs, ifn-stimulated genes, itp, immune-thrombocytopenic purpura, jak, janus kinase, ldh, lactate dehydrogenase, m, membrane, mab, monoclonal ab, mda-5, melanoma differentiation-associated protein, mers-cov, middle east respiratory syndrome coronavirus, mis-c, multisystem inflammatory syndrome in children, n, nucleocapsid, net, nuclear extracellular traps, nf-κb, nuclear factor-kappa b, nk, natural killer, nlrp3, nod-like receptor family, pyrin domain containing 3, orf, open reading frame, pacs, post-active covid-19 syndrome, pad-4, peptidylarginine deiminase 4, pamps, pathogen-associated molecular patterns, pdc, plasmacytoid dendritic cells, pmn, polymorphonuclear leukocytes, prrs, pattern recognition receptors, ra, rheumatoid arthritis, rbd, receptor binding domain, rf, rheumatoid factor, rig-i, retinoic acid-inducible gene i, ros, reactive oxygen species, rt-pcr, reverse transcription polymerase chain reaction, s, spike, sad, systemic autoimmune disease, sars-cov2, severe acute respiratory coronavirus 2, sjs, primary sjögren's syndrome, sle, systemic lupus erythematosus, ssc, systemic sclerosis, ssrna, single-stranded ribonucleic acid, stat, signal transducer and activator of transcription, tcr, t cell receptor, tlr, toll-like receptor, tmprss2, transmembrane serine protease 2, tnf, tumor necrosis factor, treg, regulatory t cells, vdj, variable, diversity and joining ig genes