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      Prevalence of depression among hypothyroid patients attending the primary healthcare and endocrine clinics of King Fahad Hospital of the University (KFHU)

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          Abstract

          Context:

          Hypothyroidism is the most prevalent endocrine disorder worldwide, with a prevalence of 4%–5%. Thyroid hormone has a role in neurological development, and hormone deficiency can be manifested by many neurological signs and symptoms such as behavioral disturbances, anxiety, and depressive symptoms.

          Aims:

          To estimate the prevalence of depression among hypothyroid patients attending primary healthcare and endocrine clinic of King Fahad Hospital of the University (KFHU) and to assess the relationship between depression and different factors.

          Settings and Design:

          A cross-sectional study was conducted to estimate the prevalence of depression among hypothyroid patients attending the primary healthcare and endocrine clinics of KFHU in Al Khobar.

          Materials and Methods:

          Patients were screened for depression using Patient Health Questionnaire-9 screening tool, in addition to obtaining their sociodemographic data, details of their thyroid function status, and other risk factors for depression. Also, patient medical files were used to obtain the laboratory results.

          Statistical Analysis Used:

          Data were analyzed using the Statistical Package for the Social Science (SPSS) version 23. Continuous data were displayed using mean and standard deviation; categorical data were displayed in numbers and percentage. Chi-square test was used to assess the relationship between the variables. A P value of less than 0.05 was considered as statistically significant.

          Results:

          It was found that 33.9% of patients were depressed with varying degree of depression. Certain symptoms were found to be associated with higher risk of depression such as fatigue, memory problems, hair loss, and gland enlargement.

          Conclusion:

          Depression was concluded to be prevalent among hypothyroid patients. And screening for depression among hypothyroid patients is recommended.

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          Most cited references23

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          An arabic translation, reliability, and validation of Patient Health Questionnaire in a Saudi sample

          Background Psychological disorders including depression and anxiety are not rare in primary care clinics. The Patient Health Questionnaire (PHQ) is a clinical diagnostic tool that is widely utilized by primary health care physicians worldwide because it provides a practical in-clinic tool to screen for psychological disorders. This study evaluated the validity of the Arabic version of the PHQ in all six modules including depression, anxiety, somatic, panic, eating, and alcohol abuse disorders. Methods This is a quantitative observational cross-sectional study that was conducted by administrating the translated Arabic version of PHQ to a sample of King Saud University students in Riyadh, Saudi Arabia. Results The sample was 731 university students who participated in this study including 376 (51.6%) females and 354 (48.4%) males with a mean age of 21.30 years. Eight mental health experts carried out the face validation process of the PHQ Arabic version. The internal consistency reliability was measured using Cronbach’s alpha for the PHQ9, GAD7, PHQ15, and panic disorder modules. The results were 0.857, 0.763, 0.826, and 0.696, respectively. In comparison, the eating disorders and alcohol abuse modules demonstrated poor internal consistency due to small number of participants in these modules. Conclusion This study demonstrates that the Arabic version of the PHQ is a valid and reliable tool to screen for depression, anxiety, somatic, and panic disorders in a Saudi sample.
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            Prevalence of hypothyroidism in adults: An epidemiological study in eight cities of India.

            Hypothyroidism is believed to be a common health issue in India, as it is worldwide. However, there is a paucity of data on the prevalence of hypothyroidism in adult population of India.
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              Use of isotretinoin and risk of depression in patients with acne: a systematic review and meta-analysis

              Objective This study aimed to investigate the association between the use of isotretinoin and the risk of depression in patients with acne. Design This was a meta-analysis in which the standardised mean difference (SMD) and the relative risk (RR) were used for data synthesis employing the random-effects model. Setting Studies were identified via electronic searches of PubMed, Embase and the Cochrane Library from inception up to 28 December 2017. Participants Patients with acne. Interventions Studies comparing isotretinoin with other interventions in patients with acne were included. Results Twenty studies were selected. The analysis of 17 studies showed a significant association of the use of isotretinoin with improved symptoms compared with the baseline before treatment (SMD = −0.33, 95% CI −0.51 to −0.15, p<0.05; I 2=76.6%, p<0.05)). Four studies were related to the analysis of the risk of depression. The pooled data indicated no association of the use of isotretinoin with the risk of depressive disorders (RR=1.15, 95% CI 0.60 to 2.21, p=0.14). The association of the use of isotretinoin with the risk of depressive disorders was statistically significant on pooling retrospective studies (RR=1.39, 95% CI 1.05 to 1.84, p=0.02), but this association was not evident on pooling prospective studies (RR=0.85, 95% CI 0.60 to 2.21, p=0.86). Conclusions This study suggested an association of the use of isotretinoin in patients with acne with significantly improved depression symptoms. Future randomised controlled trials are needed to verify the present findings.
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                Author and article information

                Journal
                J Family Med Prim Care
                J Family Med Prim Care
                JFMPC
                Journal of Family Medicine and Primary Care
                Wolters Kluwer - Medknow (India )
                2249-4863
                2278-7135
                August 2019
                28 August 2019
                : 8
                : 8
                : 2708-2713
                Affiliations
                [1 ] Medical Intern, Collage of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
                [2 ] Department of Family and Community Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
                Author notes
                Address for correspondence: Dr. Maryam Y. H. Mohammad, Medical Intern, Collage of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia. E-mail: maryamyaqoot@ 123456gmail.com
                Article
                JFMPC-8-2708
                10.4103/jfmpc.jfmpc_456_19
                6753820
                31548961
                e2f897b5-0f19-40b7-ad21-25b1aa1a641c
                Copyright: © 2019 Journal of Family Medicine and Primary Care

                This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.

                History
                : 11 June 2019
                : 24 June 2019
                : 12 July 2019
                Categories
                Original Article

                depression,hypothyroidism,patient health questionnaire-9

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