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      The projected burden of primary total knee and hip replacement for osteoarthritis in Australia to the year 2030

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          Abstract

          Background

          Comprehensive national joint replacement registries with well-validated data offer unique opportunities for examining the potential future burden of hip and knee osteoarthritis (OA) at a population level. This study aimed to forecast the burden of primary total knee (TKR) and hip replacements (THR) performed for OA in Australia to the year 2030, and to model the impact of contrasting obesity scenarios on TKR burden.

          Methods

          De-identified TKR and THR data for 2003–2013 were obtained from the Australian Orthopaedic Association National Joint Replacement Registry. Population projections and obesity trends were obtained from the Australian Bureau of Statistics, with public and private hospital costs sourced from the National Hospital Cost Data Collection. Procedure rates were projected according to two scenarios: (1) constant rate of surgery from 2013 onwards; and (2) continued growth in surgery rates based on 2003–2013 growth. Sensitivity analyses were used to estimate future TKR burden if: (1) obesity rates continued to increase linearly; or (2) 1–5% of the overweight or obese population attained a normal body mass index.

          Results

          Based on recent growth, the incidence of TKR and THR for OA is estimated to rise by 276% and 208%, respectively, by 2030. The total cost to the healthcare system would be $AUD5.32 billion, of which $AUD3.54 billion relates to the private sector. Projected growth in obesity rates would result in 24,707 additional TKRs totalling $AUD521 million. A population-level reduction in obesity could result in up to 8062 fewer procedures and cost savings of up to $AUD170 million.

          Conclusions

          If surgery trends for OA continue, Australia faces an unsustainable joint replacement burden by 2030, with significant healthcare budget and health workforce implications. Strategies to reduce national obesity could produce important TKR savings.

          Electronic supplementary material

          The online version of this article (10.1186/s12891-019-2411-9) contains supplementary material, which is available to authorized users.

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          Most cited references47

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          Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

          Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013), we estimated these quantities for acute and chronic diseases and injuries for 188 countries between 1990 and 2013.
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            Projections of Primary and Revision Hip and Knee Arthroplasty in the United States from 2005 to 2030

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              The global burden of rheumatoid arthritis: estimates from the global burden of disease 2010 study.

              To estimate the global burden of rheumatoid arthritis (RA), as part of the Global Burden of Disease 2010 study of 291 conditions and how the burden of RA compares with other conditions. The optimum case definition of RA for the study was the American College of Rheumatology 1987 criteria. A series of systematic reviews were conducted to gather age-sex-specific epidemiological data for RA prevalence, incidence and mortality. Cause-specific mortality data were also included. Data were entered into DisMod-MR, a tool to pool available data, making use of study-level covariates to adjust for country, region and super-region random effects to estimate prevalence for every country and over time. The epidemiological data, in addition to disability weights, were used to calculate years of life lived with disability (YLDs). YLDs were added to the years of life lost due to premature mortality to estimate the overall burden (disability-adjusted life years (DALYs)) for RA for the years 1990, 2005 and 2010. The global prevalence of RA was 0.24% (95% CI 0.23% to 0.25%), with no discernible change from 1990 to 2010. DALYs increased from 3.3 million (M) (95% CI 2.6 M to 4.1 M) in 1990 to 4.8 M (95% CI 3.7 M to 6.1 M) in 2010. This increase was due to a growth in population and increase in aging. Globally, of the 291 conditions studied, RA was ranked as the 42nd highest contributor to global disability, just below malaria and just above iodine deficiency (measured in YLDs). RA continues to cause modest global disability, with severe consequences in the individuals affected. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
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                Author and article information

                Contributors
                +61 3 9903 0585 , ilana.ackerman@monash.edu
                bohensky@icloud.com
                ella.zomer@monash.edu
                marktacey@gmail.com
                alexandra.gorelik@gmail.com
                brandcaroline15@gmail.com
                richard.desteiger@epworth.org.au
                Journal
                BMC Musculoskelet Disord
                BMC Musculoskelet Disord
                BMC Musculoskeletal Disorders
                BioMed Central (London )
                1471-2474
                23 February 2019
                23 February 2019
                2019
                : 20
                : 90
                Affiliations
                [1 ]ISNI 0000 0004 1936 7857, GRID grid.1002.3, Department of Epidemiology and Preventive Medicine, , Monash University, ; 553 St Kilda Road, Melbourne, Victoria 3004 Australia
                [2 ]ISNI 0000 0001 2179 088X, GRID grid.1008.9, Department of Medicine (Royal Melbourne Hospital), , The University of Melbourne, ; Grattan Street, Parkville, Victoria 3050 Australia
                [3 ]ISNI 0000 0004 0399 9112, GRID grid.416536.3, The Northern Hospital, ; 185 Cooper Street, Epping, Victoria 3076 Australia
                [4 ]ISNI 0000 0001 2179 088X, GRID grid.1008.9, School of Population and Global Health, The University of Melbourne, ; 235 Bouverie Street, Carlton, Victoria 3053 Australia
                [5 ]ISNI 0000 0001 2194 1270, GRID grid.411958.0, School of Psychology, Australian Catholic University, ; 215 Spring Street, Melbourne, Victoria 3000 Australia
                [6 ]ISNI 0000 0001 2179 088X, GRID grid.1008.9, Department of Surgery, , Epworth HealthCare, The University of Melbourne, ; 89 Bridge Road, Richmond, Victoria 3121 Australia
                [7 ]GRID grid.430453.5, Australian Orthopaedic Association National Joint Replacement Registry, , South Australian Health and Medical Research Institute, ; North Terrace, Adelaide, South Australia 5000 Australia
                Author information
                http://orcid.org/0000-0002-6028-1612
                Article
                2411
                10.1186/s12891-019-2411-9
                6387488
                30797228
                e3f8acfc-242f-4dcd-ae4a-fb42a4417eeb
                © The Author(s). 2019

                Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

                History
                : 29 August 2018
                : 8 January 2019
                Funding
                Funded by: FundRef http://dx.doi.org/10.13039/501100000925, National Health and Medical Research Council;
                Award ID: 520004
                Categories
                Research Article
                Custom metadata
                © The Author(s) 2019

                Orthopedics
                economic burden of disease,obesity,osteoarthritis,total knee replacement,total hip replacement

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