In the history of surgical oncology, survival benefit of extended lymphadenectomy
has been a focus of debates in gastrointestinal carcinomas.1 The fear for the invisible
metastasis prompted surgeons to perform more aggressive resections with lymphadenectomy
to control the disease locally. However, the clinical significance of extended lymphadenectomy
has been the subject of controversy over the past 10 years.2–4 On the other hand,
the histopathological status of regional lymph nodes is one of the most reliable predictors
of recurrence and overall survival for most gastrointestinal cancer, and it is often
used to justify stratification of patients for adjuvant therapy.
Gastric cancer is the second leading cause of cancer death worldwide; it is particularly
common in Asian countries, including Japan. To date, several classifications of lymph
node metastasis is considered for patients with gastric cancer. Classification was
based on the anatomical location of nodal involvement has been established in the
Japanese Gastric Cancer Association. The total number of involved lymph nodes is also
considered as the N status defined by the American Joint Committee on Cancer (AJCC)
and the International Union Against Cancer (UICC). In the 5th and 6th editions of
the AJCC/UICC tumor, node, metastasis system (TNM) classification, the N status for
gastric cancer was defined as follows: N0, no regional lymph node metastasis; N1,
metastasis in 1–6 regional lymph nodes; N2, metastasis in 7–15 regional lymph nodes;
and N3, metastasis in ≥16 regional lymph nodes. On the other hand, in the most recent
UICC TNM staging system (7th edition) redefined N status is categorized into N0, no
regional lymph node metastasis; N1, metastasis in 1–3 regional lymph nodes; N2, metastasis
in 4–6 regional lymph nodes; N3a, metastasis in 7–15 regional lymph nodes; and N3b,
metastasis in ≥ 16 regional lymph nodes. A recent article by Deng et al. indicated
that the 7th edition UICC N status would provide more reliable prognostic information
than the 5th/6th edition UICC N status by analysis of the 456 patients with gastric
cancer after curative surgery.5 However, N status by the AJCC/UICC TNM staging is
restricted by regional lymphadenectomy, in which at least 15 lymph nodes should be
examined, because stage migration that results from the number of dissected lymph
nodes is frequently recognized as one of the major concerns in the AJCC/UICC staging
system for gastric cancer.
Recent investigations have emphasized the clinical utility of a new lymph node staging
(N ratio) that is based on the number of positive lymph nodes divided by the number
of examined lymph nodes.6,7 Inoue et al. showed that the N ratio was the most statistically
significant prognostic factor, whereas the N status by the AJCC/UICC staging system
was not found to be significant by multivariate analysis of the 1019 patients with
gastric cancer who underwent R0 resection.6 Recently Bando et al. also reported that
the N ratio was well correlated with prognosis for 777 patients with advanced gastric
cancer, as an independent prognostic factor in a multivariate analysis.7 Moreover,
the N ratio was a statistically significant prognostic factor in N1, N2, and N3 patients
defined by the Japanese classification of disease.
The current article by Maduekwe et al. reports on the N ratio in 257 patients undergoing
D1 lymphadenectomy for gastric cancer.8 The authors note that there was no statistically
significant difference in overall survival between patients with <15 and ≥15 nodes
examined when they stratified N ratio intervals. They concluded that the N ratio is
more reliable as a prognostic indicator minimizing stage migration compared to the
N status by the 6th edition AJCC/UICC TNM staging system, even in patients with D1
lymphadenectomy in which <15 lymph nodes were excised. The article may represent a
valuable signpost for the future direction of the lymph node staging system. If the
N ratio is really feasible even to the patients with D1 lymphadenectomy, discrepancy
in prognosis of gastric cancer patients between Japan and Western countries, which
is partly believed to be the result of stage migration, could be avoided. However,
its results should be interpreted in context with caution. First, the authors set
up a unique category, Nr0, which was designated only for patients with no lymph node
metastasis among ≥15 lymph nodes examined, but not for patients with <15 nodes. If
Nr0 disease was indicated even in patients with <15 nodes examined, the survival of
patients with Nr0 and Nr1 disease who had <15 nodes examined might be much worse than
that Nr0 and Nr1 disease in patients with ≥15 nodes, respectively. Is their stratification
universally applicable to every institution in the world?
Second, unfortunately, the current article from Maduekwe et al. was based on the retrospective
review of a smaller number of patients compared to previous reports.6–9 Sun et al.
recently showed the similar results that the N ratio has advantages in minimizing
stage migration for patients with insufficient number of lymph nodes excised or patients
with D1 lymphadenectomy from their series of 2159 patients with gastric cancer.9 Because
the study of Maduekwe et al. was also mentioned in the article, the new N ratio stratification
should be validated by a large prospective study in the future.8
Third, are there any therapeutic effects of extended lymphadenectomy or resection
of more lymph nodes? In Japan and other Asian countries, extensive (D2) lymphadenectomy
has been performed as standard procedures for mid to advanced gastric cancer because
it is believed that extensive lymphadenectomy is effective in controlling the disease
locally. To date, two large European randomized trial that compared D1 with D2 lymphadenectomy,
the Dutch trial and British Medical Research Council Trial, both failed to show a
survival benefit in the favor of D2 dissection.2,3 However, these trials have been
criticized for poor quality of surgical techniques and extremely high mortality rate
(10 and 13%) after D2 lymphadenectomy. If D2 lymphadenectomy is performed with low
morbidity and mortality, it is likely to have a marked benefit compared to D1 lymphadenectomy.2,3,10
A recent Taiwanese trial comparing D1 with D2+α proved a modest survival benefit for
D2+α dissection over D1, with statistical significance, although the trial had several
issues to resolve.4
Clinical benefit of D1/D2 lymphadenectomy for gastric cancer in terms of accurate
staging and locoregional control should be validated by carefully designed multicenter
prospective randomized trials in Western and/or Asian countries. Further exploration
may clarify where it should be positioned in surgical oncology for gastric cancer.