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      Ergotamine Gangrene in Various Inflammatory Conditions


      Journal of Vascular Research

      S. Karger AG

      Ergotamine, Gangrene, Thrombosis, Inflammation, Lathyrism

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          Given in subtoxic doses to the rat, ergotamine produced tail gangrene in not more than 20% of animals. The incidence rate of ergotamine gangrene was not influenced by acute Mammation (carrageenin, dextran oedema). However, when inflammation was produced by immersing the tail of the rat in dimethyl sulfoxide, the incidence rate of ergotamine gangrene was greatly increased. The gangrene-inducing effect of ergotamine was significantly increased in rats with adjuvant arthritis or 6-sulphanylamido-indazole arthritis. Like arthritic rats, rats with lathyrism due to chronic treatment with aminoacetonitrile were also more sensitive to the gangrene-inducing effect of ergotamine. Ergotamine-induced tail gangrene in adjuvant arthritic rats is a good model for use in research for drugs which are effective against the vascular complications of ‘collagen’ diseases.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          18 September 2008
          : 8
          : 1
          : 57-64
          EGYT Pharmacochemical Works and Otto Korvin Hospital, Budapest
          157860 Angiologica 1971;8:57–64
          © 1971 S. Karger AG, Basel

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          Page count
          Pages: 8


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