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      Drugs Affecting the Cholinergic System in the Intact Mammalian Eye

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      Ophthalmic Research

      S. Karger AG

      Acetylcholine, Miotic activity, Cholinesterase inhibitors, Mouse intact eye

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          The effects of concentration and pH on the miotic activity of four cholinesterase inhibitors were studied in the intact mouse eye: while eserine (physostigmine) behaved in a dose-dependent manner, the other 3 drugs – phospholine-iodide, tacrine and diisopropylfluorophosphate showed no dose dependency in the concentration range investigated. On the other hand, the latter 2 inhibitors exhibited a marked pH dependency. The different structural features of these drugs, which may contribute to the observed difference in miotic pattern are presented and discussed.

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          03 December 2009
          : 9
          : 5
          : 289-295
          Department of Biochemistry, The George S. Wise Center for Life Sciences, Tel-Aviv University, Tel-Aviv, and Department of Ophthalmology, The Haim Sheba Medical Center, Tel-Aviv University, Tel-Hashomer
          264897 Ophthalmic Res 1977;9:289–295
          © 1977 S. Karger AG, Basel

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          Page count
          Pages: 7


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