Contributors
Rachel J. Church:
ORCID: http://orcid.org/0000-0002-1080-6046
Role: ConceptualizationRole: Formal analysisRole: MethodologyRole: Project administrationRole:
Writing – original draftRole: Writing – review & editing
Shelli J. Schomaker: Role: ConceptualizationRole: InvestigationRole: MethodologyRole: Project administrationRole:
Writing – original draftRole: Writing – review & editing
J. Scott Eaddy: Role: InvestigationRole: Project administrationRole: Resources
Germaine G. Boucher: Role: Formal analysisRole: InvestigationRole: VisualizationRole: Writing – review
& editing
John M. Kreeger: Role: Formal analysisRole: InvestigationRole: VisualizationRole: Writing – review
& editing
Jiri Aubrecht: Role: ConceptualizationRole: ResourcesRole: SupervisionRole: Writing – original draftRole:
Writing – review & editing
Paul B. Watkins: Role: ConceptualizationRole: SupervisionRole: Writing – original draftRole: Writing
– review & editing
Matias A. Avila: Role: Editor
Journal
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS One
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
9
October
2020
Publication date Collection: 2020
Volume: 15
Issue: 10
Electronic Location Identifier: e0240562
Affiliations
[1
]
Institute for Drug Safety Sciences, University of North Carolina at Chapel Hill, Chapel
Hill, North Carolina, United States of America
[2
]
Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy,
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States
of America
[3
]
Pfizer Inc., Groton, Connecticut, United States of America
University of Navarra School of Medicine and Center for Applied Medical Research (CIMA),
SPAIN
Author notes
Competing Interests: Authors SJS, GGB, JMK, and JA were employees of Pfizer Inc. at the time this study
was completed. This does not alter our adherence to PLOS ONE policies on sharing data
and materials.
[¤]
Current address: Takeda Pharmaceuticals, Cambridge, Massachusetts, United States of
America
‡ These authors are joint senior authors on this work.
Author information
Article
Publisher ID:
PONE-D-20-22783
DOI: 10.1371/journal.pone.0240562
PMC ID: 7546462
PubMed ID: 33035276
SO-VID: e7ea8c99-6860-4354-9018-05356cb6a44b
Copyright © © 2020 Church et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
History
Date
received
: 22
July
2020
Date
accepted
: 28
September
2020
Page count
Figures: 6,
Tables: 0,
Pages: 12
Funding
This study was a collaboration between authors PBW and RJC at the University of North
Carolina at Chapel Hill and author JA who was at Pfizer when this study was completed.
The in-life animal study was performed at UNC (by JSE) while clinical chemistry, histopathology,
and electron microscopy were performed at Pfizer (by authors SJS, GGB, and JA). No
money was exchanged between UNC and Pfizer for this work; both UNC and Pfizer used
internal discretionary funding for this collaboration. Pfizer provided support in
the form of salaries for authors (SJS, GGB, JMK, and JA), but did not have any additional
role in the study design, data collection and analysis, decision to publish, or preparation
of the manuscript. The specific roles of these authors are articulated in the “authors
contributions” section.
Categories
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Bioenergetics
Subject:
Energy-Producing Organelles
Subject:
Mitochondria
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Structures and Organelles
Subject:
Energy-Producing Organelles
Subject:
Mitochondria
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Plasma
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Plasma
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Plasma
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Biomarkers
Subject:
Research and Analysis Methods
Subject:
Separation Processes
Subject:
Centrifugation
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Hepatocytes
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Liver
Subject:
Hepatocytes
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Liver
Subject:
Hepatocytes
Subject:
Research and Analysis Methods
Subject:
Microscopy
Subject:
Electron Microscopy
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Blood
Subject:
Plasma Volume
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Blood
Subject:
Plasma Volume
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Body Fluids
Subject:
Blood
Subject:
Plasma Volume
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Blood
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Blood
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Body Fluids
Subject:
Blood
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