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      Surfactante pulmonar exógeno en adultos con síndrome de dificultad respiratoria aguda Translated title: Pulmonary surfactant exogenous in adults with acute respiratory distress syndrome

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          Abstract

          Objetivo: Determinar el efecto del surfactante pulmonar (Surfacen®) en la recuperación de la oxigenación en adultos con síndrome de dificultad respiratoria aguda (SDRA). Material y métodos: Adultos entre 18 y 75 años con SDRA, se incluyeron (48 pacientes) en un ensayo clínico fase II, controlado, aleatorizado y multicéntrico. Un grupo (24) recibió tratamiento de surfactante pulmonar cada ocho horas, durante tres días, en dosis de 100 mg totales, junto al tratamiento estándar (oxigenación y ventilación mecánica). El grupo control (24) sólo recibió el tratamiento estándar. El efecto se evaluó a través del índice PaO2/FiO2, la distensibilidad estática (Cs) y la radiografía de tórax. Otras variables estudiadas fueron la mortalidad, días de intubación, de ventilación mecánica (VM) y de estancia en la Unidad de Cuidados Intensivos (UCI). Resultados: Existieron diferencias estadísticamente significativas (p = 0.0399) entre los grupos en el índice PaO2/FiO2, la Cs (p = 0.005). No hubo diferencias estadísticas en la radiografía de tórax (p = 0.7177), la mortalidad (0.3652), días de intubación endotraqueal (p = 0.2659), de VM (p = 0.3582) y estancia en la UCI (p = 0.2941). Conclusiones: El uso del surfactante pulmonar (Surfacen®) junto al tratamiento estándar en adultos con SDRA mejoró significativamente la oxigenación.

          Translated abstract

          Objective: To determine the effect of the lung surfactant (Surfacen®) in the recovery of the oxygenation in adults with acute respiratory distress syndrome (ARDS). Material and methods: Adults between 18 and 75 years with acute respiratory distress syndrome, were included (48 patients) in a clinical trial phase II, controlled, randomized and multicentric. A group (24) received treatment of lung surfactant every eight hours, during three days, in dose of 100 total mg, next to the standard treatment (oxygenation and ventilation mechanics). The group control (24) alone received the standard treatment. The effect was evaluated through the index PaO2/FiO2, compliance (Cs) and the thorax X-Ray. Other studied variables were the mortality, days of intubation, of ventilation mechanics (VM) and of stay in the Unit of Intensive Cares (UCI). Results: It existed differences statistically significant (p=0.0399) among the groups in the index PaO2/FiO2, compliance (p = 0.005). There were not statistical differences in the thorax X-Ray (p = 0.7177), the mortality (p = 0.3652), days of intubation endotracheal (p = 0.2659), of ventilation mechanics (p = 0.3582) and stay in the UCI (p = 0.2941). Conclusions: The use of the lung surfactant (Surfacen®) next to the standard treatment in adults with ARDS improved oxygenation significantly.

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          Most cited references 24

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          Prevalence of Acute Lung Injury Among Medical Patients in the Emergency Department

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            Acute respiratory distress syndrome: the Berlin definition

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              Exogenous natural surfactant for treatment of acute lung injury and the acute respiratory distress syndrome

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                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Journal
                nct
                Neumología y cirugía de tórax
                Neumol. cir. torax
                Sociedad Mexicana de Neumología y Cirugía de Tórax; Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas; Sociedad Cubana de Neumología; Sociedad Paraguaya de Neumología; Sociedad Boliviana de Neumología.
                0028-3746
                September 2015
                : 74
                : 3
                : 172-178
                Affiliations
                [1 ] Centro Nacional Coordinador de Ensayos Clínicos Cuba
                [2 ] Ministerio de Salud Pública Cuba
                [3 ] Centro Nacional de Sanidad Agropecuaria Cuba
                Article
                S0028-37462015000300002

                This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 International License.

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                Product Information: website
                Categories
                Allergy
                Critical Care Medicine
                Respiratory System

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