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Abstract
Against the current concept of abortive regeneration of axotomized neurons in the
mammalian central nervous system, the occurrence of remarkable axonal regeneration
of cerebellothalamic projection neurons following transection of the decussation of
the superior cerebellar peduncle was proved in kittens morphologically by utilizing
anterograde axonal transport of horseradish peroxidase and electrophysiologically
by recording the cerebellar-induced cerebral cortical potential. Following axotomy,
not only axonal regeneration occurred but also retrograde degeneration of somata which
was apparently noticeable as cell loss. The extent of cerebellar nuclear cell loss
was inversely related to the extent of regeneration of cerebellofugal axons.