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      Prediction of Relapse by Plasma Lipoprotein(a) Concentration in Children with Steroid-Sensitive Nephrotic Syndrome


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          Aim: To clarify whether plasma lipoproteins, including Lp(a), can predict relapse pattern in the first years after diagnosis of nephrotic syndrome (NS), we evaluated them in patients with steroid-sensitive NS. Methods: We analyzed the medical records of 35 patients with steroid-sensitive NS who were seen by us from January 1992 to December 1999 followed for at least 1 year. These patients were divided into two groups. Group 1 consisted of 20 patients who infrequently relapse (IR: <2 in 6 months or <3 in a year), group 2 consisted of 15 patients who frequently relapse (FR: ≥2 in 6 months or ≥3 in a year). Clinical and laboratory findings such as age at onset, gender, urinalysis, serum level of total protein, albumin, and concentrations of serum lipid including lipoprotein(a) (Lp(a)) were investigated between group 1 and group 2. Results: The concentration of plasma Lp(a) in group 2 was higher than that in group 1 (81.0 ± 35.2 vs. 35.9 ± 26.5 mg/dl, p < 0.01). On multivariate analysis using logistic regression model, the concentration of plasma Lp(a) was an independent risk factor for relapse of NS. Conclusions: Our findings suggest that of all the laboratory data examined, high values of Lp(a) can predict future relapse of NS and should be well documented.

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          Most cited references3

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          Risk factors for relapse in childhood nephrotic syndrome.

          We investigated the risk factors for relapse in 48 children with steroid-sensitive nephrotic syndrome using univariate and multivariate proportional hazard analysis. All patients were treated with the same corticosteroid regimen. A low serum level of total protein and young age at onset increased the relapse rate. Recurrence risk was not associated with the patient's sex, the percentage body weight gain, blood urea nitrogen level, serum level of creatinine, the hematocrit, or the administration of human albumin. We conclude that young age and a low serum level of total protein at onset were independent risk factors for relapse of childhood nephrotic syndrome.
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            Plasma lipoprotein (a) levels in children with minimal lesion nephrotic syndrome

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              Changes in serum lipoprotein(a) levels in children with corticosensitive nephrotic syndrome


                Author and article information

                S. Karger AG
                October 2002
                18 October 2002
                : 92
                : 4
                : 807-811
                Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan
                65452 Nephron 2002;92:807–811
                © 2002 S. Karger AG, Basel

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                : 15 May 2002
                Page count
                Figures: 1, Tables: 4, References: 16, Pages: 5
                Self URI (application/pdf): https://www.karger.com/Article/Pdf/65452
                Self URI (text/html): https://www.karger.com/Article/FullText/65452
                Self URI (journal page): https://www.karger.com/SubjectArea/Nephrology
                Original Paper

                Cardiovascular Medicine,Nephrology
                Children,Lipoprotein(a),Steroid-sensitive nephrotic syndrome


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