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Soluplus/TPGS mixed micelles for dioscin delivery in cancer therapy.
Jing Zhao
1 ,
Youwei Xu
1 ,
Changyuan Wang
1 ,
Yanfang Ding
1 ,
Manyu Chen
1 ,
Yifei Wang
1 ,
Jinyong Peng
1 ,
Lei Li
1 ,
Li Lv
1
Jul 2017
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Abstract
Dioscin has shown cytotoxicity against cancer cells, but its poor solubility and stability have limited its clinical application. In this study, we designed mixed micelles composed of TPGS and Soluplus(®) copolymers entrapping the poorly soluble anticancer drug dioscin.