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      Psychological stress induces hypoferremia through the IL-6-hepcidin axis in rats.

      Biochemical and Biophysical Research Communications

      Animals, Antibodies, Monoclonal, pharmacology, Antimicrobial Cationic Peptides, metabolism, Cation Transport Proteins, Down-Regulation, Hepcidins, Interleukin-6, antagonists & inhibitors, Iron, blood, Liver, Male, Rats, Rats, Sprague-Dawley, Stress, Psychological, Up-Regulation

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          Abstract

          Anemia is a widespread public health problem. The psychological stress decreases serum iron level and inhibits erythropoiesis. However, the molecular mechanisms involved, leading to iron mal-regulation are not well known. We used a communication box paradigm to induce psychological stress and found that serum iron level decreased after 3d while liver iron storage increased after 7d. Moreover, psychological stress up-regulated expressions of interleukin-6 (IL-6) and hepcidin, while down-regulating ferroportin expression after 3d. These changes were blocked by the injection of IL-6 monoclonal antibody. In conclusion, the IL-6-hepcidin axis is up-regulated by psychological stress in rats, resulting in hypoferremia and increase of hepatic iron storage.

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          Journal
          18541141
          10.1016/j.bbrc.2008.05.166

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