For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
10
views
36
references
 Top references
cited by
0
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      379
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Outbreak of Serratia marcescens in the Neonatal Intensive Care Unit of a Tertiary Care Hospital in Mexico

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Introduction

          We describe an outbreak of Serratia marcescens ( S. marcescens) infection in the neonatal intensive care unit at Women's Hospital in Sinaloa, Mexico.

          Methods

          In April 2021, an outbreak of S. marcescens infection was identified. A case was identified as any patient who tested positive for S. marcescens and showed signs of an infectious process.

          Results

          S. marcescens was isolated from the blood cultures of 15 neonates with clinical signs of neonatal sepsis. Statistical analysis showed that all neonates had an invasive medical device. The problem was controlled after hospital hygiene and sanitation measures were strengthened.

          Conclusion

          The study provides evidence of an outbreak of nosocomial bacteremia due to the cross-transmission of S. marcescens. The findings highlight the need for hospitals to implement strict hygiene measures, especially regarding hand washing, to prevent future outbreaks.

          Related collections

          Most cited references36

          • Record: found
          • Abstract: not found
          • Article: not found

          Sepsis definitions: time for change.

          Jean-Louis Vincent, Steven M Opal, John C Marshall … (2013)
          Article 0 comments Cited 209 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Serratia infections: from military experiments to current practice.

            Steven Mahlen (2011)
            Serratia species, in particular Serratia marcescens, are significant human pathogens. S. marcescens has a long and interesting taxonomic, medical experimentation, military experimentation, and human clinical infection history. The organisms in this genus, particularly S. marcescens, were long thought to be nonpathogenic. Because S. marcescens was thought to be a nonpathogen and is usually red pigmented, the U.S. military conducted experiments that attempted to ascertain the spread of this organism released over large areas. In the process, members of both the public and the military were exposed to S. marcescens, and this was uncovered by the press in the 1970s, leading to U.S. congressional hearings. S. marcescens was found to be a certain human pathogen by the mid-1960s. S. marcescens and S. liquefaciens have been isolated as causative agents of numerous outbreaks and opportunistic infections, and the association of these organisms with point sources such as medical devices and various solutions given to hospitalized patients is striking. Serratia species appear to be common environmental organisms, and this helps to explain the large number of nosocomial infections due to these bacteria. Since many nosocomial infections are caused by multiply antibiotic-resistant strains of S. marcescens, this increases the danger to hospitalized patients, and hospital personnel should be vigilant in preventing nosocomial outbreaks due to this organism. S. marcescens, and probably other species in the genus, carries several antibiotic resistance determinants and is also capable of acquiring resistance genes. S. marcescens and S. liquefaciens are usually identified well in the clinical laboratory, but the other species are rare enough that laboratory technologists may not recognize them. 16S rRNA gene sequencing may enable better identification of some of the less common Serratia species.
            Article 0 comments Cited 208 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: found
              Is Open Access

              Impact of delayed admission to intensive care units on mortality of critically ill patients: a cohort study

              Lucienne TQ Cardoso, Cintia Grion, Tiemi Matsuo … (2011)
              Introduction When the number of patients who require intensive care is greater than the number of beds available, intensive care unit (ICU) entry flow is obstructed. This phenomenon has been associated with higher mortality rates in patients that are not admitted despite their need, and in patients that are admitted but are waiting for a bed. The purpose of this study is to evaluate if a delay in ICU admission affects mortality for critically ill patients. Methods A prospective cohort of adult patients admitted to the ICU of our institution between January and December 2005 were analyzed. Patients for whom a bed was available were immediately admitted; when no bed was available, patients waited for ICU admission. ICU admission was classified as either delayed or immediate. Confounding variables examined were: age, sex, originating hospital ward, ICU diagnosis, co-morbidity, Acute Physiology and Chronic Health Evaluation (APACHE) II score, therapeutic intervention, and Sequential Organ Failure Assessment (SOFA) score. All patients were followed until hospital discharge. Results A total of 401 patients were evaluated; 125 (31.2%) patients were immediately admitted and 276 (68.8%) patients had delayed admission. There was a significant increase in ICU mortality rates with a delay in ICU admission (P = 0.002). The fraction of mortality risk attributable to ICU delay was 30% (95% confidence interval (CI): 11.2% to 44.8%). Each hour of waiting was independently associated with a 1.5% increased risk of ICU death (hazard ratio (HR): 1.015; 95% CI 1.006 to 1.023; P = 0.001). Conclusions There is a significant association between time to admission and survival rates. Early admission to the ICU is more likely to produce positive outcomes.
              Article 0 comments Cited 129 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Adrian Canizalez-Roman:
                ORCID: https://orcid.org/0000-0001-8605-0639
                Journal
                Journal ID (nlm-ta): Adv Med
                Journal ID (iso-abbrev): Adv Med
                Journal ID (publisher-id): AMED
                Title: Advances in Medicine
                Publisher: Hindawi
                ISSN (Print): 2356-6752
                ISSN (Electronic): 2314-758X
                Publication date Collection: 2023
                Publication date (Electronic): 21 September 2023
                Volume: 2023
                Electronic Location Identifier: 3281910
                Affiliations
                1The Women's Hospital, Secretariat of Health, Culiacan Sinaloa 80020, Mexico
                2School of Medicine, Autonomous University of Sinaloa, Culiacan Sinaloa 80019, Mexico
                3Pediatric Hospital of Sinaloa, Culiacan Sinaloa 80200, Mexico
                4The Sinaloa State Public Health Laboratory, Secretariat of Health, Culiacan Sinaloa 80020, Mexico
                Author notes

                Academic Editor: Gagandeep Saggu

                Author information
                https://orcid.org/0000-0001-8605-0639
                Article
                DOI: 10.1155/2023/3281910
                PMC ID: 10539092
                PubMed ID: 37780054
                SO-VID: e9ec382e-d8c9-4e71-ab15-79a10fd8c2ef
                Copyright © Copyright © 2023 Martha Guel-Gomez et al.
                License:

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 28 July 2023
                Date revision received : 12 September 2023
                Date accepted : 14 September 2023
                Categories
                Subject: Research Article

                Data availability:

                Comments

                Comment on this article