Utility and safety of bronchoscopy during SARS-CoV-2 outbreak in Italy: a retrospective, multicenter study

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the related disease (coronavirus disease – 2019, COVID-19) has been notified throughout Italy since February 2020. Intensive care unit (ICU) admission rate increased following the high incidence of pneumonia-related respiratory failure [1].

Abstract

Utility and safety of bronchoscopy during SARS-CoV-2 outbreak

Related collections

Most cited references 13

Record: found
Abstract: found
Article: not found

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang, Yeming Wang, Xingwang Li … (2020)

Summary Background A recent cluster of pneumonia cases in Wuhan, China, was caused by a novel betacoronavirus, the 2019 novel coronavirus (2019-nCoV). We report the epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of these patients. Methods All patients with suspected 2019-nCoV were admitted to a designated hospital in Wuhan. We prospectively collected and analysed data on patients with laboratory-confirmed 2019-nCoV infection by real-time RT-PCR and next-generation sequencing. Data were obtained with standardised data collection forms shared by WHO and the International Severe Acute Respiratory and Emerging Infection Consortium from electronic medical records. Researchers also directly communicated with patients or their families to ascertain epidemiological and symptom data. Outcomes were also compared between patients who had been admitted to the intensive care unit (ICU) and those who had not. Findings By Jan 2, 2020, 41 admitted hospital patients had been identified as having laboratory-confirmed 2019-nCoV infection. Most of the infected patients were men (30 [73%] of 41); less than half had underlying diseases (13 [32%]), including diabetes (eight [20%]), hypertension (six [15%]), and cardiovascular disease (six [15%]). Median age was 49·0 years (IQR 41·0–58·0). 27 (66%) of 41 patients had been exposed to Huanan seafood market. One family cluster was found. Common symptoms at onset of illness were fever (40 [98%] of 41 patients), cough (31 [76%]), and myalgia or fatigue (18 [44%]); less common symptoms were sputum production (11 [28%] of 39), headache (three [8%] of 38), haemoptysis (two [5%] of 39), and diarrhoea (one [3%] of 38). Dyspnoea developed in 22 (55%) of 40 patients (median time from illness onset to dyspnoea 8·0 days [IQR 5·0–13·0]). 26 (63%) of 41 patients had lymphopenia. All 41 patients had pneumonia with abnormal findings on chest CT. Complications included acute respiratory distress syndrome (12 [29%]), RNAaemia (six [15%]), acute cardiac injury (five [12%]) and secondary infection (four [10%]). 13 (32%) patients were admitted to an ICU and six (15%) died. Compared with non-ICU patients, ICU patients had higher plasma levels of IL2, IL7, IL10, GSCF, IP10, MCP1, MIP1A, and TNFα. Interpretation The 2019-nCoV infection caused clusters of severe respiratory illness similar to severe acute respiratory syndrome coronavirus and was associated with ICU admission and high mortality. Major gaps in our knowledge of the origin, epidemiology, duration of human transmission, and clinical spectrum of disease need fulfilment by future studies. Funding Ministry of Science and Technology, Chinese Academy of Medical Sciences, National Natural Science Foundation of China, and Beijing Municipal Science and Technology Commission.

0 comments Cited 22286 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: found

Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy

Giacomo Grasselli, Alberto Zangrillo, Alberto Zanella … (2020)

In December 2019, a novel coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) emerged in China and has spread globally, creating a pandemic. Information about the clinical characteristics of infected patients who require intensive care is limited.

0 comments Cited 2819 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: found

Detection of SARS-CoV-2 in Different Types of Clinical Specimens

Wenling Wang, Yanli Xu, Ruqin Gao … (2020)

This study describes results of PCR and viral RNA testing for SARS-CoV-2 in bronchoalveolar fluid, sputum, feces, blood, and urine specimens from patients with COVID-19 infection in China to identify possible means of non-respiratory transmission.

0 comments Cited 2413 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Journal

Journal ID (nlm-ta): Eur Respir J

Journal ID (iso-abbrev): Eur. Respir. J

Journal ID (publisher-id): ERJ

Journal ID (hwp): erj

Title: The European Respiratory Journal

Publisher: European Respiratory Society

ISSN (Print): 0903-1936

ISSN (Electronic): 1399-3003

Publication date (Electronic): 28 August 2020

Publication date PMC-release: 28 August 2020

Electronic Location Identifier: 2002767

Affiliations

[1 ]Respiratory Unit, ASST Santi Paolo e Carlo, San Paolo Hospital, Department of Health Sciences, Università degli Studi di Milano, Milan, Italy

[2 ]Department of Health Sciences, Università degli Studi di Milano, Milan, Italy

[3 ]Dipartimento di Scienze Neuroriabilitative, Casa di Cura del Policlinico, Milan, Italy

[4 ]School of Medicine and Surgery, University of Milano Bicocca, Respiratory Unit, San Gerardo Hospital, ASST Monza, Monza, Italy

[5 ]ASST Lodi, UOC Medicina Interna, Lodi, Italy

[6 ]ASST Lodi, UOC Pneumologia, Lodi, Italy

[7 ]Respiratory Unit, Papa Giovanni XXIII Hospital, Bergamo, Italy

[8 ]Respiratory Unit, Papa Giovanni XXIII Hospital, Department of Health Sciences, Università degli Studi di Milano, Bergamo, Italy

[9 ]Respiratory Diseases Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

[10 ]Respiratory Diseases Unit, Fondazione IRCCS Policlinico San Matteo, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy

[11 ]Pulmonary Disease Unit, Department of Internal Medicine, Azienda Ospedali Riuniti, Department of Biomedical Sciences and Public Health, Università Politecnica delle Marche, Ancona, Italy

[12 ]Clinical Epidemiology and Medical Statistics Unit, Dept of Medical, Surgical and Experimental Medicine, University of Sassari, Sassari, Italy

Author notes

Dr Michele Mondoni, Respiratory Unit, ASST Santi Paolo e Carlo, San Paolo Hospital, Department of Health Sciences, Università degli Studi di Milano, Via A. Di Rudinì n.8, 20142, Milan, Italy. E-mail: michele.mondoni@ 123456asst-santipaolocarlo.it

Author information

Simone Pasini https://orcid.org/0000-0002-8009-6182

Fabiano Di Marco https://orcid.org/0000-0002-1743-0504

Laura Saderi https://orcid.org/0000-0002-5131-9367

Giovanni Sotgiu https://orcid.org/0000-0002-1600-4474

Article

Publisher ID: ERJ-02767-2020

DOI: 10.1183/13993003.02767-2020

PMC ID: 7453732

PubMed ID: 32859682

SO-VID: eae735cc-1113-4c67-9fee-865836e92ac2

License:

This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.

History

Date received : 5 June 2020

Date accepted : 5 August 2020

Funding

Funded by: Università degli Studi di Milano , open-funder-registry 10.13039/100012352;

Utility and safety of bronchoscopy during SARS-CoV-2 outbreak in Italy: a retrospective, multicenter study

Read this article at

Abstract

Abstract

Related collections

Novel Coronavirus Disease COVID-19

Most cited references 13

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy

Detection of SARS-CoV-2 in Different Types of Clinical Specimens

Author and article information

Journal

Affiliations

Author notes

Author information

Article

History

Funding

Categories

Comments

Comment on this article

Similar content 252

Cited by 19

Most referenced authors 1,838