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      The HSP90 inhibitor 17-AAG potentiates the antileishmanial activity of the ether lipid edelfosine.

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          Abstract

          HSP90 is an abundant protein in Leishmania parasites that plays a major role in the parasite survival under stress conditions. Here we found that the HSP90 inhibitor 17-AAG (≥100nM 17-AAG) induced cell cycle arrest at G0/G1 in Leishmania infantum and Leishmania panamensis promastigotes, and highly potentiated the induction of cell death by an apoptotic-like process mediated by the ether phospholipid edelfosine (5-20μM). These data suggest that the combined treatment of 17-AAG and edelfosine might be a novel and effective approach of combination therapy in the treatment of leishmaniasis.

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          Author and article information

          Journal
          Acta Trop.
          Acta tropica
          Elsevier BV
          1873-6254
          0001-706X
          Mar 2014
          : 131
          Affiliations
          [1 ] Instituto de Biología Molecular y Celular del Cáncer, Centro de Investigación del Cáncer, CSIC-Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain.
          [2 ] Laboratorio de Inmunología Parasitaria y Molecular, IBSAL-CIETUS, Facultad de Farmacia, Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain.
          [3 ] Instituto de Biología Molecular y Celular del Cáncer, Centro de Investigación del Cáncer, CSIC-Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain. Electronic address: fmollin@usal.es.
          Article
          S0001-706X(13)00341-0
          10.1016/j.actatropica.2013.11.018
          24299925

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