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Abstract
By using the reverse transcriptase polymerase chain reaction technique, the expression
of 5-hydroxytryptamine (5-HT) receptor subtype mRNAs in the rat lumbar dorsal root
ganglion (DRG) was investigated following unilateral injection of complete Freund's
adjuvant (CFA) into the rat hind paw. The results showed that 5-HT(1A), 5-HT(1B),
5-HT(1D), 5-HT(1F), 5-HT(2A), 5-HT(3), 5-HT(4), 5-HT(5A) and 5-HT(7) receptor subtypes
were present in the rat lumbar DRG. CFA injection resulted in a significant increase
in mRNA level of 5-HT(1A), 5-HT(1B), 5-HT(1F), 5-HT(2A), 5-HT(3), 5-HT(4) and 5-HT(7)
receptor subtypes and a marked induction of 5-HT(2C) subtype mRNA in the DRG. The
present results suggest the important roles for these 5-HT receptor subtypes in generating
peripheral nociceptive signaling and provide evidence to elucidate the mechanism of
5-HT in nociception.