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      Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study.

      Science (New York, N.Y.)

      Adult, Aged, Aged, 80 and over, Analysis of Variance, Case-Control Studies, Confidence Intervals, Disease Susceptibility, Humans, Insulin-Like Growth Factor Binding Protein 3, blood, Insulin-Like Growth Factor I, analysis, Insulin-Like Growth Factor II, Male, Middle Aged, Odds Ratio, Prospective Studies, Prostate-Specific Antigen, Prostatic Neoplasms, etiology, Reference Values, Regression Analysis, Risk, Risk Factors

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          Abstract

          Insulin-like growth factor-I (IGF-I) is a mitogen for prostate epithelial cells. To investigate associations between plasma IGF levels and prostate cancer risk, a nested case-control study within the Physicians' Health Study was conducted on prospectively collected plasma from 152 cases and 152 controls. A strong positive association was observed between IGF-I levels and prostate cancer risk. Men in the highest quartile of IGF-I levels had a relative risk of 4.3 (95 percent confidence interval 1.8 to 10.6) compared with men in the lowest quartile. This association was independent of baseline prostate-specific antigen levels. Identification of plasma IGF-I as a predictor of prostate cancer risk may have implications for risk reduction and treatment.

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          9438850

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