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      Hemodynamic Effects of Transdermal Nitroglycerin Patches in Patients with Acute Myocardial Infarction

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          Abstract

          Transdermal nitroglycerin patches are used mainly in the therapy of angina pectoris. However, the magnitude and duration of their effects are still controversial. In this study, transdermal discs with nitroglycerin were given to 14 patients with acute myocardial infarction (AMI) and mild hemodynamic impairment. Seven patients received Nitroderm® TTS, and seven patients Deponit® 5 (in this case 2 patches), the nitroglycerin dose being 10 mg. Hemodynamic measurements were made 19–24 h after application of the patch and 1 h after its removal. Comparing with the values obtained 1 h after removal of the patch, 19–24 h after the application of the patch heart rate was significantly higher (90.2 ± 3.8 vs. 85.6 ± 4.0 min<sup>-1</sup>; p < 0.01), mean right atrial pressure was significantly lower (10.8 ± 1.0 vs. 12.7 ± 1.3 mm Hg; p < 0.01), and so were the pulmonary artery pressure: systolic (36.9 ± 3.0 vs. 43.0 ± 3.1 mm Hg; p < 0.001), mean (26.8 ± 2.1 vs. 31.4 ± 2.0 mm Hg; p < 0.001) and the capillary wedge pressure (19.2 ± 1.8 vs. 23.0 ± 1.9 mm Hg; p < 0.01). These findings revealed that in patients with AMI hemodynamic effects persist for at least 19 h after single application of a nitroglycerin patch of 10 mg. The therapy is safe and the risk of side effects is small.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          978-3-8055-5486-2
          978-3-318-01618-5
          0008-6312
          1421-9751
          1991
          1991
          12 November 2008
          : 79
          : Suppl 2
          : 58-62
          Affiliations
          Faculty of Medicine, J.E. Pukyne University, Brno, Czechoslovakia
          Article
          174926 Cardiology 1991;79:58–62
          10.1159/000174926
          1760832
          © 1991 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
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