Screening and Severity of Coronavirus Disease 2019 (COVID-19) in Children in Madrid, Spain

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

This case series describes the testing for and treatment of children with coronavirus disease 2019 (COVID-19) in Madrid, Spain.

Related collections

Most cited references 1

Record: found
Abstract: found
Article: found

Is Open Access

Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR

Victor M Corman, Olfert Landt, Marco Kaiser … (2020)

Background The ongoing outbreak of the recently emerged novel coronavirus (2019-nCoV) poses a challenge for public health laboratories as virus isolates are unavailable while there is growing evidence that the outbreak is more widespread than initially thought, and international spread through travellers does already occur. Aim We aimed to develop and deploy robust diagnostic methodology for use in public health laboratory settings without having virus material available. Methods Here we present a validated diagnostic workflow for 2019-nCoV, its design relying on close genetic relatedness of 2019-nCoV with SARS coronavirus, making use of synthetic nucleic acid technology. Results The workflow reliably detects 2019-nCoV, and further discriminates 2019-nCoV from SARS-CoV. Through coordination between academic and public laboratories, we confirmed assay exclusivity based on 297 original clinical specimens containing a full spectrum of human respiratory viruses. Control material is made available through European Virus Archive – Global (EVAg), a European Union infrastructure project. Conclusion The present study demonstrates the enormous response capacity achieved through coordination of academic and public laboratories in national and European research networks.

0 comments Cited 3499 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Journal

Title: JAMA Pediatrics

Abbreviated Title: JAMA Pediatr

Publisher: American Medical Association (AMA)

ISSN (Print): 2168-6203

Publication date (Electronic): April 08 2020

Affiliations

[1 ]Hospital Universitario Infanta Sofía. Universidad Europea de Madrid. Madrid, Spain

[2 ]Fundación para la Investigación Biomédica del Hospital 12 de Octubre, Madrid, Spain

[3 ]Hospital Universitario 12 de Octubre, Pediatric Infectious Disease Unit, Madrid, Spain

[4 ]Hospital Universitario Gregorio Marañón, Pediatric Infectious Diseases Unit, Madrid, Spain

[5 ]Hospital Universitario Niño Jesús, Pediatrics Department, Madrid, Spain

[6 ]Hospital Universitario Ramon y Cajal, Pediatrics Department, Madrid, Spain

[7 ]Pediatrics and Infectious Disease Unit, Hospital Universitario La Paz; Fundación IdiPaz, Madrid, España; European Network of Excellence for Pediatric Clinical Research; Red de Investigación Traslacional en Infectología Pediátrica

Article

DOI: 10.1001/jamapediatrics.2020.1346

PMC ID: 7142799

PubMed ID: 32267485

SO-VID: edcfd6f2-7d8a-469e-b7be-665e6900b0d0

History

Data availability:

Comments

Comment on this article

scite_

Cited by 186

See all cited by

Most referenced authors 422

See all reference authors

- Version 1