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      Long-term antidepressant treatment decreases spiroperidol-labeled serotonin receptor binding.

      Science (New York, N.Y.)
      Animals, Antidepressive Agents, administration & dosage, metabolism, pharmacology, Frontal Lobe, drug effects, Male, Rats, Receptors, Adrenergic, alpha, Receptors, Adrenergic, beta, Receptors, Dopamine, Receptors, Histamine H1, Receptors, Muscarinic, Receptors, Serotonin, Spiperone, Time Factors

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          Abstract

          Antidepressants compete at several neurotransmitter receptor binding site, but drug affinities do not correlate with clinical efficacy. Long-term, but not short-term, antidepressant treatment decreases the numbers of both serotonin and beta-adrenergic receptors. The decrease in the number of receptor sites is most marked for [3H]spiroperidol-labeled serotonin receptors and is characteristic for antidepressants of several classes.

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