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      Long-term antidepressant treatment decreases spiroperidol-labeled serotonin receptor binding.

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      Publication date:
      Journal: Science (New York, N.Y.)
      Keywords: Animals, Antidepressive Agents, administration & dosage, metabolism, pharmacology, Frontal Lobe, drug effects, Male, Rats, Receptors, Adrenergic, alpha, Receptors, Adrenergic, beta, Receptors, Dopamine, Receptors, Histamine H1, Receptors, Muscarinic, Receptors, Serotonin, Spiperone, Time Factors

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          Abstract

          Antidepressants compete at several neurotransmitter receptor binding site, but drug affinities do not correlate with clinical efficacy. Long-term, but not short-term, antidepressant treatment decreases the numbers of both serotonin and beta-adrenergic receptors. The decrease in the number of receptor sites is most marked for [3H]spiroperidol-labeled serotonin receptors and is characteristic for antidepressants of several classes.

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          Journal
          PubMed ID:: 6251550
          DOI:: 10.1126/science.6251550

          ScienceOpen disciplines: Chemistry
          Keywords: Animals,Antidepressive Agents,administration & dosage,metabolism,pharmacology,Frontal Lobe,drug effects,Male,Rats,Receptors, Adrenergic, alpha,Receptors, Adrenergic, beta,Receptors, Dopamine,Receptors, Histamine H1,Receptors, Muscarinic,Receptors, Serotonin,Spiperone,Time Factors
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          ScienceOpen disciplines: Chemistry
          Keywords: Animals, Antidepressive Agents, administration & dosage, metabolism, pharmacology, Frontal Lobe, drug effects, Male, Rats, Receptors, Adrenergic, alpha, Receptors, Adrenergic, beta, Receptors, Dopamine, Receptors, Histamine H1, Receptors, Muscarinic, Receptors, Serotonin, Spiperone, Time Factors

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