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      Resuscitation with hypertonic saline-dextran reduces serum biomarker levels and correlates with outcome in severe traumatic brain injury patients.

      Journal of Neurotrauma

      Treatment Outcome, Adult, therapeutic use, Saline Solution, Hypertonic, blood, S100 Proteins, S100 Calcium Binding Protein beta Subunit, methods, Resuscitation, Regression Analysis, Phosphopyruvate Hydratase, Nerve Growth Factors, Myelin Basic Protein, Injury Severity Score, Humans, Fluid Therapy, Enzyme-Linked Immunosorbent Assay, Double-Blind Method, Dextrans, therapy, Brain Injuries, Biological Markers, Analysis of Variance

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          Abstract

          In the treatment of severe traumatic brain injury (TBI), the choice of fluid and osmotherapy is important. There are practical and theoretical advantages to the use of hypertonic saline. S100B, neuron-specific enolase (NSE), and myelin-basic protein (MBP) are commonly assessed biomarkers of brain injury with potential utility as diagnostic and prognostic indicators of outcome after TBI, but they have not previously been studied in the context of fluid resuscitation. This randomized controlled trial compared serum concentrations of S100B, NSE, and MBP in adult severe TBI patients resuscitated with 250 mL of 7.5% hypertonic saline plus 6% dextran70 (HSD; n = 31) versus 0.9% normal saline (NS; n = 33), and examined their relationship with neurological outcome at discharge. Blood samples drawn on admission (

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          Journal
          10.1089/neu.2008.0868
          19637968

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