Central Obesity, Leptin and Cognitive Decline: The Sacramento Area Latino Study on Aging

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Background/Aims: Central obesity is a risk factor for cognitive decline. Leptin is secreted by adipose tissue and has been associated with better cognitive function. Aging Mexican Americans have higher levels of obesity than non-Hispanic Whites, but no investigations examined the relationship between leptin and cognitive decline among them or the role of central obesity in this association. Methods: We analyzed 1,480 dementia-free older Mexican Americans who were followed over 10 years. Cognitive function was assessed every 12–15 months with the Modified Mini Mental State Exam (3MSE) and the Spanish and English Verbal Learning Test (SEVLT). Results: For females with a small waist circumference (≤35 inches), an interquartile range difference in leptin was associated with 35% less 3MSE errors and 22% less decline in the SEVLT score over 10 years. For males with a small waist circumference (≤40 inches), an interquartile range difference in leptin was associated with 44% less 3MSE errors and 30% less decline in the SEVLT score over 10 years. There was no association between leptin and cognitive decline among females or males with a large waist circumference. Conclusion: Leptin interacts with central obesity in shaping cognitive decline. Our findings provide valuable information about the effects of metabolic risk factors on cognitive function.

Related collections

Author and article information

Journal

Journal ID (publisher-id): DEM

Journal ID (nlm-ta): Dement Geriatr Cogn Disord

Journal ID (doi): 10.1159/issn.1420-8008

Title: Dementia and Geriatric Cognitive Disorders

Publisher: S. Karger AG

ISSN (Print): 1420-8008

ISSN (Electronic): 1421-9824

Publication date Subscription-year: 2012

Publication date (Print): August 2012

Publication date (Electronic): 17 July 2012

Volume: 33

Issue: 6

Pages: 400-409

Affiliations

Departments of ^aEpidemiology and Biostatistics and ^bPsychiatry, School of Medicine, University of California San Francisco, San Francisco, Calif., and ^cKaiser Permanente, Northern California Division of Research, Oakland, Calif., USA

Author notes

*Adina Zeki Al Hazzouri, PhD, MSc, University of California, San Francisco, School of Medicine, Department of Epidemiology and Biostatistics, 185 Berry St., Lobby 5, Suite 5700, San Francisco, CA 94107 (USA), Tel. +1 415 514 8261, E-Mail Adina.zekialhazzouri@ucsf.edu

Article

Publisher ID: 339957 Pmcid ID: PMC3483312 Other ID: Dement Geriatr Cogn Disord 2012;33:400–409

DOI: 10.1159/000339957

PMC ID: PMC3483312

PubMed ID: 22814127

SO-VID: eec8e100-64be-432a-a950-633dd7298552

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date accepted : 06 June 2012

Page count

Figures: 2, Tables: 3, Pages: 10

Comments

Comment on this article

scite_

Cited by 24

See all cited by

- Version 1

Call for Papers: Sex and Gender in Neurodegenerative Diseases

Submit here before September 30, 2024