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      Adenoid Cystic Carcinoma of Bartholin’s Gland Clinically Mimics Endometriosis, A Case Report

      case-report

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          Abstract

          Adenoid cystic carcinoma of Bartholin’s gland is a rare malignant tumor of female genital tract. We report a case of a 42-year-old woman, presenting a palpable painful mass and burning sensation on the left side of vulva during the preceding two months. Based on examination, a solid fixed painful nodule with intact mucosa was palpated on the left side of the vagina. Histological features were compatible with adenoid cystic carcinoma. Often, such lesion is clinically misdiagnosed as a cyst or inflammation. The present case was carried out with an impression of endometriosis. The possibility of cancer should be considered in any female older than 40 years of age with a lesion near the Bartholin’s glands.

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          Adenoid cystic carcinoma of the Bartholin's gland: report of two cases and review of the literature.

          Woo Jean Kim, Duk Soo Bae, Joo Yong Lee … (2006)
          Adenoid cystic carcinoma (ACC) of the Bartholin's gland is a rare malignancy of the female genital tract and there have been 62 cases of ACC of the Bartholin's gland in the literature. Two cases of ACC of the Bartholin's gland are reported. There is no consensus on optimal treatment of ACC of the Bartholin's gland. Most commonly, wide local excision and radical vulvectomy with or without lymph node dissection, are performed. More long-term follow up is recommended to evaluate optimal primary treatment and roles of radiotherapy and chemotherapy because ACC of the Bartholin's gland recurs and metastasizes long after primary treatment.
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            Bartholin's gland carcinoma: a 15-year experience.

            J. Fiorica, R Cardosi, Robert Hoffman … (2001)
            Our objective was to review our experience with carcinoma of Bartholin's gland relative to treatment and oncologic outcome. Patient names were collected from our vulvar cancer database for the period September 1985 to September 2000. The medical records were retrospectively reviewed, and data were abstracted relative to demographics, presenting symptoms, treatment, and oncologic outcome. We treated 12 women with Bartholin's gland carcinoma, and 11 patients are reported. Seven women presented with a painless vulvar mass, and 8 of 11 had initially been treated for an infectious process before referral to our institution. Squamous histology was most common, and the right gland was more frequently involved. Ten patients were treated with primary surgery, followed by adjuvant radiation in 7 for inadequate resection margins or lymphatic metastases. One patient was treated with primary chemoradiation. Stage I, II, III, IVA, and IVB disease was present in 3, 1, 4, 2, and 1 patient, respectively. Recurrence was suffered by 54.5% during a mean follow-up time of 73.5 months (median, 60; range, 8-180 months). Overall survival is 58.3% to date. Conventional therapy for Bartholin's gland carcinoma yielded a 67% 5-year survival. Seventy-one percent of women receiving adjuvant radiotherapy recurred despite this precaution. Work is needed to identify an effective systemic therapy and to better determine which patients may benefit from pelvic radiotherapy. Copyright 2001 Academic Press.
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              Adenoid cystic carcinoma of the Bartholin gland: an overview.

              Alfredo Ribeiro-da-Silva, Francesca Woida (2007)
              Vulvar carcinoma is the fourth most frequently encountered malignancy of the female reproductive tract. Among vulvar neoplasms, 0.1% to 5% are of Bartholin gland origin. Primary adenoid cystic carcinoma of the Bartholin gland is very rare. To date, only about 60 cases have been reported in the world literature. Microscopic examination reveals a neoplasm of cribriform pattern composed of nests and columns of cells of bland appearance arranged concentrically around glandlike spaces filled with eosinophilic periodic acid-Schiff-positive diastase-resistant material. Immunohistochemically, the tumor cells express low-molecular-weight keratins, carcinoembryonic antigen, lysozyme, alpha1-antichymotrypsin, S100, and type IV collagen. Adenoid cystic carcinoma of the Bartholin gland is a slow-growing but locally very aggressive neoplasm with high capacity for recurrence. Perineural and lymphatic invasion is characteristic of this tumor and may explain its propensity for causing pain and recurrence. The treatment may range from simple local excision to radical vulvectomy, with or without partial to complete regional lymphadenectomy.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Iran J Med Sci
                Journal ID (iso-abbrev): Iran J Med Sci
                Journal ID (publisher-id): IJMS
                Title: Iranian Journal of Medical Sciences
                Publisher: Shiraz University of Medical Sciences (Shiraz, Iran )
                ISSN (Print): 0253-0716
                ISSN (Electronic): 1735-3688
                Publication date (Print): November 2014
                Volume: 39
                Issue: 6
                Pages: 580-583
                Affiliations
                [1 ]Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;
                [2 ]Department of Gynecology and Obstetrics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
                Author notes
                Correspondence: Mojgan Akbarzadeh-Jahromi, MD; Department of Pathology, School of Medicine, Zand Avenue, P.O. Box: 71345-1864, Shiraz, Iran Tel/Fax: +98 71 32301784 Emails: akbarzadeh@sums.ac.ir mojganakbarzadeh@yahoo.com
                Article
                Publisher ID: ijms-39-580
                PMC ID: 4242995
                SO-VID: eed76ec7-479f-4fcf-bb65-0b542ba2c85f
                Copyright © © 2014: Iranian Journal of Medical Sciences
                License:

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License, ( http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 29 April 2013
                Date revision received : 9 June 2013
                Date accepted : 28 July 2013
                Categories
                Subject: Case Report

                ScienceOpen disciplines: Medicine
                Keywords: bartholin’s gland,adenoid cystic carcinoma,pain
                Data availability:
                ScienceOpen disciplines: Medicine
                Keywords: bartholin’s gland, adenoid cystic carcinoma, pain

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