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      PharmGKB: the Pharmacogenetics Knowledge Base.

      Nucleic Acids Research

      Biotransformation, genetics, Database Management Systems, Databases, Factual, Drug Therapy, Enzymes, metabolism, Genetic Variation, Genome, Human, Humans, Information Storage and Retrieval, Internet, Pharmaceutical Preparations, Pharmacogenetics, Phenotype, Polymorphism, Single Nucleotide, User-Computer Interface

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          Abstract

          The Pharmacogenetics Knowledge Base (PharmGKB; http://www.pharmgkb.org/) contains genomic, phenotype and clinical information collected from ongoing pharmacogenetic studies. Tools to browse, query, download, submit, edit and process the information are available to registered research network members. A subset of the tools is publicly available. PharmGKB currently contains over 150 genes under study, 14 Coriell populations and a large ontology of pharmacogenetics concepts. The pharmacogenetic concepts and the experimental data are interconnected by a set of relations to form a knowledge base of information for pharmacogenetic researchers. The information in PharmGKB, and its associated tools for processing that information, are tailored for leading-edge pharmacogenetics research. The PharmGKB project was initiated in April 2000 and the first version of the knowledge base went online in February 2001.

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          11752281
          99138

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