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      Excitability and NADH Fluorescence of Spontaneously Active Portal Veins in Relation to Glucose Withdrawal

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          Abstract

          The effect of glucose withdrawal upon mechanical activity and the redox level of pyridine nucleotides and flavoproteins was investigated in isolated rat portal veins under aerobic conditions. A decrease of extracellular glucose concentration correlated with contractile activity. During acetylcholine-induced tetanic contractions, NADH and flavoproteins were oxydized only in vessels supplied with glucose. The myogenic activity was restituted when glucose was added after withdrawal parallel with a reduction of NAD and flavoproteins. The results suggest that glucose, besides its effect on the energy metabolism, has an influence on the excitability of smooth muscle cells of rat portal veins.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1979
          1979
          19 September 2008
          : 16
          : 6
          : 295-301
          Affiliations
          Institute of Physiology I, University of Tübingen, Tübingen
          Article
          158219 Blood Vessels 1979;16:295–301
          10.1159/000158219
          © 1979 S. Karger AG, Basel

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          Page count
          Pages: 7
          Categories
          Original Paper

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