For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
14
views
11
references
 Top references
cited by
2
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      393
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Intramuscular Hibernoma of the Scapular Region Misdiagnosed on Cytology as a Malignant Lesion: A Report of a Rare Case

      case-report

      Read this article at

      ScienceOpenPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Hibernomas are extremely rare benign tumors of adipose tissue characterized by an admixture of brown fat cells with granular, multivacuolated cytoplasm and white fat cells. Hibernomas account for 1.6% of benign adipose tissue tumors and approximately 1.1% of all adipocytic tumors. Around 10% of these cases are intramuscular. It was initially described in the early 1900s as being composed of brown fat. Hibernomas usually occur in third to fourth decades of life and the most frequent sites being thigh, trunk, shoulder, back etc. Cytological differential diagnoses of hibernoma include well differentiated liposarcoma, myxoid/round cell liposarcoma, chondroid lipoma and benign granular cell tumor. Due to its abundant vascularity evident on angiography, it can sometimes mimic a malignant lesion, from which it needs to be distinguished as complete surgical excision is the only treatment required for a hibernoma. Moreover, it has no malignant or metastatic potential.

          We presented a rare case of intramuscular hibernoma of the scapular region in a 34-year-old male, in which cytology was reported as pleomorphic fibrolipomatous malignant lesion.

          Related collections

          Most cited references11

          • Record: found
          • Abstract: found
          • Article: not found

          The morphologic spectrum of hibernoma: a clinicopathologic study of 170 cases.

          M Miettinen, Mary Furlong, Jacqui Smith (2001)
          Hibernoma, an uncommon tumor of brown fat, has been described only in a few case reports and small series. The authors reviewed 170 cases of hibernoma and evaluated the morphologic features and the behavior of this tumor. The records from the Soft Tissue Registry of the Armed Forces Institute of Pathology from 1970 were searched for cases coded as "hibernoma." Clinical information and available slides from 170 hibernomas were reviewed. Immunohistochemical staining for S-100 and CD34 was performed on select cases. Follow-up information was obtained from the patients' medical records, the patients' physicians, and the patients themselves. Of 170 patients with hibernoma, 99 were men and 71 were women. The tumor occurred most commonly in adults, with a mean age of 38.0 years (age range, 2-75 years). Nine tumors occurred in pediatric patients. The most common anatomic locations included the thigh (n = 50), shoulder (n = 20), back (n = 17), neck (n = 16), chest (n = 11), arm (n = 11), and abdominal cavity/retroperitoneum (n = 10). The average duration of the tumor was 30.6 months. Tumor size ranged from 1 to 24 cm with an average dimension of 9.3 cm. All tumors were composed partly or principally of coarsely multivacuolated fat cells with small, central nuclei and no atypia. Four morphologic variants of hibernoma were identified: typical, myxoid, spindle cell, and lipoma-like. "Typical" hibernoma (n = 140) included eosinophilic cell, pale cell, and mixed cell types based on the tinctorial quality of the hibernoma cells. The myxoid variant (n = 14) contained a loose basophilic matrix. Spindle cell hibernoma (n = 4) had features of spindle cell lipoma and hibernoma; all occurred in the neck or scalp. The lipoma-like variant (n = 12) contained only scattered hibernoma cells. Immunohistochemically, 17 of 20 cases (85%) were positive for S-100 protein. Only one hibernoma of 20, a spindle cell variant, was positive for CD34, whereas other hibernoma variants were negative. Follow-up was obtained for 66 cases (39%) over a mean period of 7.7 years (range, 6 months-28 years). None of the patients with follow-up had a recurrence or metastasis, including eight with intramuscular tumors. No patient died of disease. Hibernoma is a tumor found most often in adults and most commonly in the thigh, with several morphologic variants. It is a benign tumor that does not recur with complete excision. Hibernomas should not be confused with atypical lipomas or well-differentiated liposarcoma.
          Article 0 comments Cited 59 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Hibernomas: clinicopathological features, diagnosis, and treatment of 17 cases.

            Andreas Mavrogenis, Luis Coll-Mesa, Gabriele Drago … (2011)
            Hibernomas are rare benign adipose tumors composed of brown fat cells with granular, multivacuolated cytoplasm admixed with white adipose tissue. They account for 1.6% of benign lipomatous tumors and approximately 1.1% of all adipocytic tumors. They are more common in the third and fourth decades of life. The most common location is the thigh, followed by the shoulder, back, and head and neck. Four histological types have been reported; abundant vascularity is characteristic, and atypias are rare. The treatment of choice for hibernomas is complete surgical excision. Metastases or malignant transformation have not been reported.This article presents a series of 17 patients with hibernomas diagnosed and treated at our institution from January 1986 to December 2009. Six men and 11 women (M:F, 1:2) had a mean age of 38 years (range, 10 months to 64 years). All patients underwent surgical treatment; 14 patients had marginal and 3 had wide excision. Adjuvants such as radiation therapy, chemotherapy, or embolization were not administered for any patient. The most common symptom was a painless palpable mass, followed by a tender or painful mass; in 2 patients, the tumor was an incidental finding. The duration of symptoms ranged from 1 month to 10 years (mean, 27 months). The most common location was the thigh, followed by the buttock, scapula, and neck. The most common histological variant was the typical variant followed by the lipoma-like variant. At a mean follow-up of 5 years (range, 1-9 years), local recurrences were not observed.
            Article 0 comments Cited 7 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Massive abdominal wall hibernoma: case report and literature review of a rare soft-tissue tumor.

              Oluwamayowa Familua, Albert Adu, Nikesh Lath … (2011)
              Hibernoma is a rare benign tumor arising from remnants of fetal brown adipose tissue. This tumor was first described by Merkel in 1906. The brown fat is a specialized form of fat found in the hibernating and nonhibernating animals such as rats, cats, monkeys, rabbits, and humans. A 27-year-old man presented with a painless, enlarging, anterior abdominal wall mass, which, upon core-needle biopsy, was found to be hibernoma. This was evaluated with abdominal computed tomography, which showed a heterogeneous mass that contained fat. At operation, the entire mass measuring 30x25x6 cm lying below the external oblique muscle was excised with a cuff of normal tissue. Hibernoma is a rare, slow-growing benign soft tissue tumor composed of brown fat that is successfully treated by complete excision while preserving all related vital structures. Unlike lipoma, hibernoma is well vascularized and therefore good hemostasis must be achieved at surgery to prevent postoperative bleeding or hematoma. No case of recurrence has been previously reported.
              Article 0 comments Cited 6 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Iran J Pathol
                Journal ID (iso-abbrev): Iran J Pathol
                Journal ID (publisher-id): IJP
                Title: Iranian Journal of Pathology
                Publisher: Iranian Society of Pathology (Tehran, Iran )
                ISSN (Print): 1735-5303
                ISSN (Electronic): 2345-3656
                Publication date (Print): Fall 2017
                Publication date (Electronic): 1 October 2017
                Volume: 12
                Issue: 4
                Pages: 406-409
                Affiliations
                [1 ] Department of Pathology, ESIC Medical College, Faridabad, India
                [2 ] Department of Pathology, Hamdard Institute of Medical Sciences & Research, Jamia Hamdard, New Delhi, India
                [3 ] Department of Oncosurgery, RJSP Cancer Hospital, Ranchi, India
                Author notes
                [* ]Corresponding Information: Dr. Sujata Jetley, MBBS, MD (Pathology), Professor & Head, Dept. of Pathology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, New Delhi, E-mail: drjetley2013@gmail.com
                Article
                Publisher ID: ijp-12-406
                PMC ID: 5844688
                SO-VID: ef687fd6-87ab-4a5f-8455-f4e6c55b3162
                Copyright © © 2017, IRANIAN JOURNAL OF PATHOLOGY.
                License:

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License, ( http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 20 June 2016
                Date accepted : 28 December 2016
                Categories
                Subject: Case Report

                Keywords: hibernoma,benign lipomatous tumor,brown fat,intramuscular hibernoma,scapular
                Data availability:
                Keywords: hibernoma, benign lipomatous tumor, brown fat, intramuscular hibernoma, scapular

                Comments

                Comment on this article